Journal
NATURE COMMUNICATIONS
Volume 10, Issue -, Pages -Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/s41467-019-09775-w
Keywords
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Categories
Funding
- Cancer Research UK [C1298/A25514, C348/A12076, C6199/A16459, C1287/A10118, C1287/A16563, C490/A10124, C5047/A7357, C5047/A3354, C5047/A10692, C16913/A6135]
- National Cancer Research Network
- European Union [FP7/207-2013] [258236]
- FP7 collaborative project SYSCOL
- COST Action in the UK [BM1206]
- Cancer Research UK
- Medical Research Council
- National Institute of Health Research Cancer Research Network
- Bobby Moore Fund from Cancer Research UK
- Tenovus
- Kidani Trust
- Cancer Research Wales
- National Institute for Social Care and Health Research Cancer Genetics Biomedical Research Unit
- Wellcome Trust [090532/Z/09/Z, 104036/Z/14/Z, 068545/Z/02]
- Age UK
- Biotechnology and Biological Sciences Research Council (BBSRC) [BB/F019394/1]
- BBSRC
- Medical Research Council RC as part of the LLHW [MR/K026992/1]
- Cancer Research UK CDF [C31250/A22804]
- Chief Scientist Office of the Scottish Government Health Directorates [CZD/16/6]
- Scottish Funding Council [HR03006]
- Medical Research Council UK
- Marie Sklodowska-Curie Intra-European Fellowship Action
- Academy of Finland [250345, 312041, 271642, 263164, 100499, 205585, 265240, 263278]
- Jane and Aatos Erkko Foundation
- Finnish Cancer Society
- European Research Council [ERC] [268648]
- Sigrid Juselius Foundation
- SYSCOL
- Nordic Information for Action eScience Center (NIASC)
- Nordic Center of Excellence - NordForsk [62721]
- Ministry of Education and Culture, Finland
- Finnish Academy [139635]
- Finnish Foundation for Cardiovascular Research
- Finnish Cancer Foundation
- Wellcome Trust Sanger Institute
- ENGAGE-European Network for Genetic and Genomic Epidemiology, FP7-HEALTH-F4-2007 [201413]
- National Institute of Alcohol Abuse and Alcoholism [AA-12502, AA-00145, K02AA018755]
- National Cancer Institute (NCI) of the National Institutes of Health (NIH) [U01 CA167551]
- NCI/NIH [U01 CA122839, R01 CA143237]
- FFG BRIDGE [829675]
- Herzfelder'sche Familienstiftung
- COST Action [BM1206]
- German Research Council (Deutsche Forschungsgemeinschaft) [BR 1704/6-1, BR 1704/6-3, BR 1704/6-4, BR 1704/6-6, CH 117/1-1]
- German Federal Ministry of Education and Research [01KH0404, 01ER0814, 01ER0815, 01ER1505A, 01ER1505B]
- 10,001 Dalmatians Project
- National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC)
- Medical Research Council [G0000934]
- Breast Cancer Now
- NHS
- European Commission (DG-SANCO)
- International Agency for Research on Cancer
- Ligue Contre le Cancer (France)
- Institut Gustave Roussy (France)
- Mutuelle Generale de l'Education Nationale (France)
- Institut National de la Sante et de la Recherche Medicale (INSERM) (France)
- German Cancer Aid (Germany)
- German Cancer Research Center (DKFZ) (Germany)
- Federal Ministry of Education and Research (BMBF) (Germany)
- Hellenic Health Foundation (Greece)
- Stavros Niarchos Foundation (Greece)
- Associazione Italiana per la Ricerca sul Cancro-AIRC-Italy (Italy)
- National Research Council (Italy)
- Dutch Ministry of Public Health, Welfare and Sports (VWS) (The Netherlands)
- Netherlands Cancer Registry (NKR) (The Netherlands)
- LK Research Funds (The Netherlands)
- Dutch Prevention Funds (The Netherlands)
- Dutch ZON (Zorg Onderzoek Nederland) (The Netherlands)
- World Cancer Research Fund (WCRF) (The Netherlands)
- Statistics Netherlands (The Netherlands)
- Health Research Fund (FIS) (Spain) [PI13/00061, PI13/01162]
- Regional Government of Andalucia (Spain)
- Regional Government of Asturias (Spain)
- Regional Government of Basque Country (Spain)
- Regional Government of Murcia (Spain)
- Regional Government of Navarra (Spain)
- ISCIII RETIC (Spain) [RD06/0020]
- Cancer Research UK (United Kingdom) [14136, C570/A16491, C8221/A19170]
- Medical Research Council (United Kingdom) [1000143, MR/M012190/1]
- UK NIHR BRC at the University of Cambridge
- Institute of Cancer Research (ICR)
- US National Institutes of Health (NIH) [U19 CA 148537, X01HG007492, HHSN268201200008I]
- NIH NCI [U01 CA188392]
- European Commission's Seventh Framework Programme [223175 (HEALTH-F2-2009-223175)]
- National Institute of Health (NIH) Cancer Post-Cancer GWAS initiative grant [1 U19 CA 148537-01]
- Institute of Cancer Research
- Everyman Campaign
- Prostate Cancer Research Foundation
- Prostate Action
- Orchid Cancer Appeal
- National Cancer Research Network UK
- National Cancer Research Institute (NCRI) UK
- NIHR
- Royal Marsden NHS Foundation Trust
- Kuopio University Hospital [B1401]
- Spanish Instituto de Salud Carlos III (ISCIII) an initiative of the Spanish Ministry of Economy and Innovation (Spain)
- Xunta de Galicia (Spain)
- Wellcome Trust [104036/Z/14/Z] Funding Source: researchfish
- European Research Council (ERC) [268648] Funding Source: European Research Council (ERC)
- Academy of Finland (AKA) [312041, 312041] Funding Source: Academy of Finland (AKA)
- BBSRC [BB/F019394/1] Funding Source: UKRI
- MRC [G0600329, MC_UU_00007/10, MR/K018647/1, MR/N01104X/2, MC_PC_U127527198, MC_U127527198, G0600237, MC_UU_12023/3, MR/M016587/1, MR/P001106/1, MC_U122861325, MR/M004007/1, MC_UU_00007/1] Funding Source: UKRI
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Colorectal cancer (CRC) is a leading cause of cancer-related death worldwide, and has a strong heritable basis. We report a genome-wide association analysis of 34,627 CRC cases and 71,379 controls of European ancestry that identifies SNPs at 31 new CRC risk loci. We also identify eight independent risk SNPs at the new and previously reported European CRC loci, and a further nine CRC SNPs at loci previously only identified in Asian populations. We use in situ promoter capture Hi-C (CHi-C), gene expression, and in silico annotation methods to identify likely target genes of CRC SNPs. Whilst these new SNP associations implicate target genes that are enriched for known CRC pathways such as Wnt and BMP, they also highlight novel pathways with no prior links to colorectal tumourigenesis. These findings provide further insight into CRC susceptibility and enhance the prospects of applying genetic risk scores to personalised screening and prevention.
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