Journal
NATURE COMMUNICATIONS
Volume 10, Issue -, Pages -Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/s41467-019-10192-2
Keywords
-
Categories
Funding
- Svenska Sallskapet for Medicinsk Forskning (SSMF)
- Swedish Research Council [K2015-99 x -22880-01-6, 2016-01653]
- Stockholm University
- Vetenskapsradet
- SSMF
- Swedish foundation for Strategic Research
- Instumentarium Science Foundation
- service of the Electron Tomography Facility at Karolinska Institutet
- Academy of Finland
- Swedish Heart-Lung Foundation [20150303]
- Karolinska Institutet
- Stockholm County Council [20140309]
- Karolinska Institutet [20140309]
- Swedish Research Council [2016-01653] Funding Source: Swedish Research Council
- MRC [MR/N024850/1] Funding Source: UKRI
Ask authors/readers for more resources
Artificial nanoparticles accumulate a protein corona layer in biological fluids, which significantly influences their bioactivity. As nanosized obligate intracellular parasites, viruses share many biophysical properties with artificial nanoparticles in extracellular environments and here we show that respiratory syncytial virus (RSV) and herpes simplex virus type 1 (HSV-1) accumulate a rich and distinctive protein corona in different biological fluids. Moreover, we show that corona pre-coating differentially affects viral infectivity and immune cell activation. In addition, we demonstrate that viruses bind amyloidogenic peptides in their corona and catalyze amyloid formation via surface-assisted heterogeneous nucleation. Importantly, we show that HSV-1 catalyzes the aggregation of the amyloid beta-peptide (A beta(42)), a major constituent of amyloid plaques in Alzheimer's disease, in vitro and in animal models. Our results highlight the viral protein corona as an acquired structural layer that is critical for viral-host interactions and illustrate a mechanistic convergence between viral and amyloid pathologies.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available