Journal
NATURE COMMUNICATIONS
Volume 10, Issue -, Pages -Publisher
NATURE PORTFOLIO
DOI: 10.1038/s41467-019-10873-y
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Funding
- Conquer Cancer Foundation
- John and Elizabeth Leonard Family Foundation Young Investigator Award
- Charles, Lilian and Betty Neuwirth Foundation Fellowship in Oncology Award
- Englander Institute for Precision Medicine at WCM
- Robert J. Kleberg Jr. and Helen C. Kleberg Foundation
- Khalifa Bin Zayed Al Nahyan Foundation
- Eleanor and Scott Petty Fund for UTUC Research, University of Texas MD Anderson Cancer Center
- Partnership for Bladder Cancer Research, Scott Department of Urology, Dan L. Duncan Cancer Center Baylor College of Medicine
- Translational Research Program at WCM Department of Pathology and Laboratory Medicine
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Upper tract urothelial carcinoma (UTUC) is characterized by a distinctly aggressive clinical phenotype. To define the biological features driving this phenotype, we performed an integrated analysis of whole-exome and RNA sequencing of UTUC. Here we report several key insights from our molecular dissection of this disease: 1) Most UTUCs are luminal-papillary; 2) UTUC has a T-cell depleted immune contexture; 3) High FGFR3 expression is enriched in UTUC and correlates with its T-cell depleted immune microenvironment; 4) Sporadic UTUC is characterized by a lower total mutational burden than urothelial carcinoma of the bladder. Our findings lay the foundation for a deeper understanding of UTUC biology and provide a rationale for the development of UTUC-specific treatment strategies.
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