Journal
EPIGENOMICS
Volume 11, Issue 10, Pages 1163-1176Publisher
FUTURE MEDICINE LTD
DOI: 10.2217/epi-2019-0093
Keywords
ceRNAs; circPLK1; circRNAs; MiR-296-5p; miRNAs; PLK1; prognosis; therapy; triple-negative breast cancer; tumor occurrence and metastasis
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Funding
- National Natural Science Foundation of China [81772961, 81872152, 81702620]
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Aim: To investigate the role of circRNAs in triple-negative breast cancer (TNBC) and the underlying mechanisms. Materials & methods: We performed circRNA microarrays to explore the expression profiles of TNBC cell lines. Experiments in vitro and in vivo were conducted to explore the effects of circPLK1 on tumor proliferation and metastasis as well as the interaction between circPLK1, miR-296-5p and PLK1 in TNBC. Results & conclusion: CircPLK1 was significantly upregulated in TNBC and associated with poor survivals. CircPLK1 knockdown inhibited cell growth and invasion in vitro as well as tumor occurrence and metastasis in vivo. CircPLK1-miR-296-5p-PLK1 axis regulates tumor progression by ceRNA mechanism in TNBC, indicating that circPLK1 may serve as a prognostic factor and novel therapeutic target for TNBC.
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