Journal
EXPERIMENTAL AND THERAPEUTIC MEDICINE
Volume 18, Issue 2, Pages 1253-1257Publisher
SPANDIDOS PUBL LTD
DOI: 10.3892/etm.2019.7696
Keywords
tuberculosis; early diagnosis
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Sensitivity and specificity of the interferon-gamma release test for active tuberculosis screening were evaluated. Due to the high-test cost of imported IGRAs, QFT-GIT and T-SPOT.TB, we applied a cheaper domestic TB-IGRA which was approved in China recently. We recruited 740 patients and performed tuberculosis interferon release test (IGRAs), detection of Mycobacterium tuberculosis IgG antibody (TB-IgG) and tuberculin skin test (TST). The sensitivity of the three methods are 90.8, 40.0 and 75.45%, with specificity of 76.62, 74.47 and 72.27%. The area under the ROC curve according to the value of T-N detected by IGRAs was 0.878 (95% CI, 0.839-0.917), with the area under the curve for the diagnosis of active pulmonary tuberculosis and extrapulmonary tuberculosis being 0.839 and 0.841 respectively. The interferon-gamma release test seems to be superior to TST and TB-IgG as a screening tool for the detection of active tuberculosis in China.
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