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EXPERIMENTAL NEUROLOGY (2006)
Soluble amyloid precursor protein a reduces neuronal injury and improves functional outcome following diffuse traumatic brain injury in rats
Emma Thornton et al.
BRAIN RESEARCH (2006)
Lipid rafts serve as a signaling platform for nicotinic acetylcholine receptor clustering
D Zhu et al.
JOURNAL OF NEUROSCIENCE (2006)
Targeting amyloid-β peptide (Aβ) oligomers by passive immunization with a conformation-selective monoclonal antibody improves learning and memory in Aβ precursor protein (APP) transgenic mice
EB Lee et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2006)
Cholesterol interacts with transmembrane α-helices M1, M3, and M4 of the Torpedo nicotinic acetylcholine receptor:: Photolabeling studies using [3H-]azicholesterol
AK Hamouda et al.
BIOCHEMISTRY (2006)
Brain neuronal nicotinic receptors as new targets for drug discovery
C Gotti et al.
CURRENT PHARMACEUTICAL DESIGN (2006)
Targeting the alpha 7 nicotinic acetylcholine receptor to reduce amyloid accumulation in Alzheimer's disease pyramidal neurons
MR D'Andrea et al.
CURRENT PHARMACEUTICAL DESIGN (2006)
Lipid rafts are involved in C95 (4,8) agrin fragment-induced acetylcholine receptor clustering
JA Campagna et al.
NEUROSCIENCE (2006)
Amyloidogenic processing of beta-amyloid precursor protein in intracellular compartments
KS Vetrivel et al.
NEUROLOGY (2006)
The involvement of lipid rafts in Alzheimer's disease (Review)
JM Cordy et al.
MOLECULAR MEMBRANE BIOLOGY (2006)
Brain nicotinic acetylcholine receptors: native subtypes and their relevance
Cecilia Gotti et al.
TRENDS IN PHARMACOLOGICAL SCIENCES (2006)
Nicotinic receptors modulate transmitter cross talk in the CNS
Susan Wonnacott et al.
JOURNAL OF MOLECULAR NEUROSCIENCE (2006)
Rafts are required for acetylcholine receptor clustering
Francoise Stetzkowski-Marden et al.
JOURNAL OF MOLECULAR NEUROSCIENCE (2006)
alpha 7 nicotinic acetylcholine receptor expression in Alzheimer's disease - Receptor densities in brain regions of the APP((SWE)) mouse model and in human peripheral blood lymphocytes
Ian W. Jones et al.
JOURNAL OF MOLECULAR NEUROSCIENCE (2006)
How principles of domain formation in model membranes may explain ambiguities concerning lipid raft formation in cells
E London
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2005)
The C-terminal peptides of acetylcholinesterase:: Cellular trafficking, oligomerization and functional anchoring
J Massoulié et al.
CHEMICO-BIOLOGICAL INTERACTIONS (2005)
Cross-seeding of wild-type and hereditary variant-type amyloid β-proteins in the presence of gangliosides
N Yamamoto et al.
JOURNAL OF NEUROCHEMISTRY (2005)
Fluorescence and molecular dynamics studies of the acetylcholine receptor γM4 transmembrane peptide in reconstituted systems
SS Antollini et al.
MOLECULAR MEMBRANE BIOLOGY (2005)
Regulation of cholesterol and sphingomyelin metabolism by amyloid-β and presenilin
MOW Grimm et al.
NATURE CELL BIOLOGY (2005)
Efficient synthesis of a β-peptide combinatorial library with microwave irradiation
JK Murray et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2005)
Expression of nicotinic receptors on primary cultures of rat astrocytes and up-regulation of the α7, α4 and β2 subunits in response to nanomolar concentrations of the β-amyloid peptide1-42
J Xiu et al.
NEUROCHEMISTRY INTERNATIONAL (2005)
Binding of amyloidogenic transthyretin to the plasma membrane alters membrane fluidity and induces neurotoxicity
X Hou et al.
BIOCHEMISTRY (2005)
Spatial segregation of γ-secretase and substrates in distinct membrane domains
KS Vetrivel et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
Desensitization of nicotinic ACh receptors: shaping cholinergic signaling
R Giniatullin et al.
TRENDS IN NEUROSCIENCES (2005)
GM1 ganglioside and the seeding of amyloid in Alzheimer's disease: Endogenous seed for alzheimer amyloid
K Yanagisawa
NEUROSCIENTIST (2005)
Proteomic identification of proteins oxidized by Aβ(1-42) in synaptosomes:: Implications for Alzheimer's disease
D Boyd-Kimball et al.
BRAIN RESEARCH (2005)
Oxidative metabolites accelerate Alzheimer's amyloidogenesis by a two-step mechanism, eliminating the requirement for nucleation
J Bieschke et al.
BIOCHEMISTRY (2005)
GM1 ganglioside-mediated accumulation of amyloid β-protein on cell membranes
M Wakabayashi et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2005)
Cholesterol homeostasis failure as a unifying cause of synaptic degeneration
AR Koudinov et al.
JOURNAL OF THE NEUROLOGICAL SCIENCES (2005)
Refined structure of the nicotinic acetylcholine receptor at 4 Å resolution
N Unwin
JOURNAL OF MOLECULAR BIOLOGY (2005)
High selective expression of α7 nicotinic receptors on astrocytes in the brains of patients with sporadic Alzheimer's disease and patients carrying Swedish APP 670/671 mutation:: a possible association with neuritic plaques
WF Yu et al.
EXPERIMENTAL NEUROLOGY (2005)
γ-secretase exists on the plasma membrane as an intact complex that accepts substrates and effects intramembrane cleavage
JH Chyung et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
The critical role of methionine 35 in Alzheimer's amyloid-β-peptide (1-42)-induced oxidative stress and neurotoxicity
DA Butterfield et al.
BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS (2005)
Nicotinic acetylcholine receptor induces lateral segregation of phosphatidic acid and phosphatidylcholine in reconstituted membranes
JJ Wenz et al.
BIOCHEMISTRY (2005)
Somato-dendritic nicotinic receptor responses recorded in vitro from the medial septal diagonal band complex of the rodent
Z Henderson et al.
JOURNAL OF PHYSIOLOGY-LONDON (2005)
Structural membrane alterations in Alzheimer brains found to be associated with regional disease development; increased density of gangliosides GM1 and GM2 and loss of cholesterol in detergent-resistant membrane domains
M Molander-Melin et al.
JOURNAL OF NEUROCHEMISTRY (2005)
Small assemblies of unmodified amyloid β-protein are the proximate neurotoxin in Alzheimer's disease
WL Klein et al.
NEUROBIOLOGY OF AGING (2004)
Phosphatidic acid and phosphatidylserine have distinct structural and functional interactions with the nicotinic acetylcholine receptor
CJB daCosta et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
Metabolite-initiated protein misfolding may trigger Alzheimer's disease
QH Zhang et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)
Reduced levels of Aβ 40 and Aβ 42 in brains of smoking controls and Alzheimer's patients
E Hellström-Lindahl et al.
NEUROBIOLOGY OF DISEASE (2004)
Involvement of oxidative stress-induced abnormalities in ceramide and cholesterol metabolism in brain aging and Alzheimer's disease
RG Cutler et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)
Insertion of the amyloid precursor protein into lipid monolayers:: effects of cholesterol and apolipoprotein E
R Lahdo et al.
BIOCHEMICAL JOURNAL (2004)
β-amyloid directly inhibits human α4β2-nicotinic acetylcholine receptors heterologously expressed in human SH-EP1 cells
J Wu et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
Neuronal membrane cholesterol loss enhances amyloid pepticle generation
J Abad-Rodriguez et al.
JOURNAL OF CELL BIOLOGY (2004)
Environment- and mutation-dependent aggregation behavior of Alzheimer amyloid β-protein
N Yamamoto et al.
JOURNAL OF NEUROCHEMISTRY (2004)
Metabolic cholesterol depletion hinders cell-surface trafficking of the nicotinic acetylcholine receptor
MF Pediconi et al.
NEUROSCIENCE (2004)
Subcellular topography of neuronal Aβ peptide in APPxPS1 transgenic mice
D Langui et al.
AMERICAN JOURNAL OF PATHOLOGY (2004)
Amyloid-induced neurofibrillary tangle formation in Alzheimer's disease:: insight from transgenic mouse and tissue-culture models
J Götz et al.
INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE (2004)
Association of γ-secretase with lipid rafts in post-golgi and endosome membranes
KS Vetrivel et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
Ca2+ permeability of nicotinic acetylcholine receptors
S Fucile
CELL CALCIUM (2004)
Contribution of glial cells to the development of amyloid plaques in Alzheimer's disease
RG Nagele et al.
NEUROBIOLOGY OF AGING (2004)
CSF markers for Alzheimer's disease:: Total Tau, phospho-tau and Aβ42
N Andreasen et al.
WORLD JOURNAL OF BIOLOGICAL PSYCHIATRY (2003)
Mouse models of Alzheimer's disease: The long and filamentous road
AL Phinney et al.
NEUROLOGICAL RESEARCH (2003)
Nicotinic acetylcholine receptor α7 regulates cAMP signal within lipid rafts
J Oshikawa et al.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (2003)
α7 nicotinic acetylcholine receptors mediate β-amyloid peptide-induced tau protein phosphorylation
HY Wang et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
Astrocytes accumulate Aβ42 and give rise to astrocytic amyloid plaques in Alzheimer disease brains
RG Nagele et al.
BRAIN RESEARCH (2003)
Roles of amyloid precursor protein and its fragments in regulating neural activity, plasticity and memory
PR Turner et al.
PROGRESS IN NEUROBIOLOGY (2003)
Differential physiologic responses of α7 nicotinic acetylcholine receptors to β-amyloid1-40 and β-amyloid1-42
DHS Lee et al.
JOURNAL OF NEUROBIOLOGY (2003)
Statin effects on cholesterol micro-domains in brain plasma membranes
C Kirsch et al.
BIOCHEMICAL PHARMACOLOGY (2003)
Cholesterol is necessary both for the toxic effect of Aβ peptides on vascular smooth muscle cells and for Aβ binding to vascular smooth muscle cell membranes
S Subasinghe et al.
JOURNAL OF NEUROCHEMISTRY (2003)
β-amyloid aggregation induced by human acetylcholinesterase:: inhibition studies
M Bartolini et al.
BIOCHEMICAL PHARMACOLOGY (2003)
The role of cholesterol in pathogenesis of Alzheimer's disease -: Dual metabolic interaction between amyloid β-protein and cholesterol
M Michikawa
MOLECULAR NEUROBIOLOGY (2003)
Regulation of transbilayer plasma membrane phospholipid asymmetry
DL Daleke
JOURNAL OF LIPID RESEARCH (2003)
Amyloidogenic processing of the Alzheimer β-amyloid precursor protein depends on lipid rafts
R Ehehalt et al.
JOURNAL OF CELL BIOLOGY (2003)
Amyloid beta-protein (A beta)1-40 protects neurons from damage induced by A beta 1-42 in culture and in rat brain
K Zou et al.
JOURNAL OF NEUROCHEMISTRY (2003)
Nicotinic α7 receptors:: Synaptic options and downstream signaling in neurons
DK Berg et al.
JOURNAL OF NEUROBIOLOGY (2002)
Amyloid β-protein affects cholesterol metabolism in cultured neurons:: Implications for pivotal role of cholesterol in the amyloid cascade
JS Gong et al.
JOURNAL OF NEUROSCIENCE RESEARCH (2002)
Metalloenzyme-like activity of Alzheimer's disease β-amyloid -: Cu-dependent catalytic conversion of dopamine, cholesterol, and biological reducing agents to neurotoxic H2O2
C Opazo et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
Segregation of phosphatidic acid-rich domains in reconstituted acetylcholine receptor membranes
JA Poveda et al.
BIOCHEMISTRY (2002)
Lipid matters: nicotinic acetylcholine receptor-lipid interactions (Review)
FJ Barrantes
MOLECULAR MEMBRANE BIOLOGY (2002)
Alzheimer's disease and the basal forebrain cholinergic system:: relations to β-amyloid peptides, cognition, and treatment strategies
DS Auld et al.
PROGRESS IN NEUROBIOLOGY (2002)
Brain membrane cholesterol domains, aging and amyloid beta-peptides
WG Wood et al.
NEUROBIOLOGY OF AGING (2002)
Cholesterol attenuates the membrane perturbing properties of β-amyloid peptides
C Kirsch et al.
AMYLOID-JOURNAL OF PROTEIN FOLDING DISORDERS (2002)
Modulation of acetylcholine receptor channel kinetics by hydrocortisone
E Nurowska et al.
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES (2002)
Neurodegenerative disease - Amyloid pores from pathogenic mutations
HA Lashuel et al.
NATURE (2002)
β-amyloid peptide activates α7 nicotinic acetylcholine receptors expressed in Xenopus oocytes
KT Dineley et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
The channel hypothesis of Alzheimer's disease: current status
BL Kagan et al.
PEPTIDES (2002)
Identification of threonine 422 in transmembrane domain αM4 of the nicotinic acetylcholine receptor as a possible site of interaction with hydrocortisone
I Garbus et al.
NEUROPHARMACOLOGY (2002)
A novel function of monomeric amyloid β-protein serving as an antioxidant molecule against metal-induced oxidative damage
K Zou et al.
JOURNAL OF NEUROSCIENCE (2002)
Interactions of amyloid β-protein with various gangliosides in raft-like membranes:: Importance of GM1 ganglioside-bound form as an endogenous seed for Alzheimer amyloid
A Kakio et al.
BIOCHEMISTRY (2002)
The origin of the molecular diversity and functional anchoring of cholinesterases
J Massoulié
NEUROSIGNALS (2002)
Aβ42-peptide assembly on lipid Bilayers
CM Yip et al.
JOURNAL OF MOLECULAR BIOLOGY (2002)
Cholesterol is an important factor affecting the membrane insertion of β-amyloid peptide (Aβ1-40), which may potentially inhibit the fibril formation
SR Ji et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
Cholesterol-dependent γ-secretase activity in buoyant cholesterol-rich membrane microdomains
S Wahrle et al.
NEUROBIOLOGY OF DISEASE (2002)
PRiMA:: The membrane anchor of acetylcholinesterase in the brain
AL Perrier et al.
NEURON (2002)
Unique effects of different fatty acid species on the physical properties of the Torpedo acetylcholine receptor membrane
SS Antollini et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
Lipid-protein interactions at the nicotinic acetylcholine receptor - A functional coupling between nicotinic receptors and phosphatidic acid-containing lipid bilayers
CJB daCosta et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
Characterisation of adducts of the lipid peroxidation product 4-hydroxy-2-nonenal and amyloid beta-peptides by liquid chromatography/electrospray ionisation mass spectrometry
F Magni et al.
RAPID COMMUNICATIONS IN MASS SPECTROMETRY (2002)
Intracellular accumulation of beta-amyloid(1-42) in neurons is facilitated by the alpha 7 nicotinic acetylcholine receptor in Alzheimer's disease
RG Nagele et al.
NEUROSCIENCE (2002)
Human Brain Nicotinic Receptors, their Distribution and Participation in Neuropsychiatric Disorders
A. J. Graham et al.
CNS & NEUROLOGICAL DISORDERS-DRUG TARGETS (2002)
Endosomal sorting of amyloid precursor protein-P-selectin chimeras influences secretase processing
BL Daugherty et al.
TRAFFIC (2001)
Amyloid β protein forms ion channels:: implications for Alzheimer's disease pathophysiology
H Lin et al.
FASEB JOURNAL (2001)
Acyl-coenzyme A:cholesterol acyltransferase modulates the generation of the amyloid β-peptide
L Puglielli et al.
NATURE CELL BIOLOGY (2001)
A novel action of Alzheimer's amyloid β-protein (Aβ):: Oligomeric Aβ promotes lipid release
M Michikawa et al.
JOURNAL OF NEUROSCIENCE (2001)
Membrane-disordering effects of β-amyloid peptides
WE Müller et al.
BIOCHEMICAL SOCIETY TRANSACTIONS (2001)
Cholesterol-dependent formation of GM1 ganglioside-bound amyloid β-protein, an endogenous seed for Alzheimer amyloid
A Kakio et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
β-amyloid activates the mitogen-activated protein kinase cascade via hippocampal α7 nicotinic acetylcholine receptors:: In vitro and in vivo mechanisms related to Alzheimer's disease
KT Dineley et al.
JOURNAL OF NEUROSCIENCE (2001)
Accumulation of amyloid β-protein in the low-density membrane domain accurately reflects the extent of β-amyloid deposition in the brain
N Oshima et al.
AMERICAN JOURNAL OF PATHOLOGY (2001)
Low cholesterol stimulates the nonamyloidogenic pathway by its effect on the α-secretase ADAM 10
E Kojro et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2001)
Characterization of high-affinity binding between gangliosides and amyloid β-protein
T Ariga et al.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS (2001)
β-Amyloid peptide blocks the response of α7-containing nicotinic receptors on hippocampal neurons
QS Liu et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2001)
Nicotinic cholinergic signaling in hippocampal astrocytes involves calcium-induced calcium release from intracellular stores
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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2001)
Vulnerability of synaptosomes from ApoE knock-out mice to structural and oxidative modifications induced by Aβ(1-40):: Implications for Alzheimer's disease
CM Lauderback et al.
BIOCHEMISTRY (2001)
Steroids differentially inhibit the nicotinic acetylcholine receptor
I Garbus et al.
NEUROREPORT (2001)
Membrane lipid rafts are necessary for the maintenance of the α7 nicotinic acetylcholine receptor in somatic spines of ciliary neurons
JL Brusés et al.
JOURNAL OF NEUROSCIENCE (2001)
beta-Amyloid(1-42) peptide directly modulates nicotinic receptors in the rat hippocampal slice
DL Pettit et al.
JOURNAL OF NEUROSCIENCE (2001)
Hydrophobic protein that copurifies with human brain acetylcholinesterase: Amino acid sequence, genomic organization, and chromosomal localization
DS Navaratnam et al.
JOURNAL OF NEUROCHEMISTRY (2000)
Cellular expression of α7 nicotinic acetylcholine receptor protein in the temporal cortex in Alzheimer's and Parkinson's disease -: A stereological approach
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NEUROBIOLOGY OF DISEASE (2000)
4-hydroxynonenal-modified amyloid-β peptide inhibits the proteasome:: possible importance in Alzheimer's disease
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CELLULAR AND MOLECULAR LIFE SCIENCES (2000)
Maturation and endosomal targeting of β-site amyloid precursor protein-cleaving enzyme -: The Alzheimer's disease β-secretase
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JOURNAL OF BIOLOGICAL CHEMISTRY (2000)
Structure and function of sphingolipid- and cholesterol-rich membrane rafts
DA Brown et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2000)
Neuronal nicotinic receptors in the human brain
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PROGRESS IN NEUROBIOLOGY (2000)
Correlation between elevated levels of amyloid β-peptide in the brain and cognitive decline
J Näslund et al.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2000)
Alzheimer's Aβ1-40 peptide modulates lipid synthesis in neuronal cultures and intact rat fetal brain under normoxic and oxidative stress conditions
NV Koudinova et al.
NEUROCHEMICAL RESEARCH (2000)
β-amyloid1-42 binds to α7 nicotinic acetylcholine receptor with high affinity -: Implications for Alzheimer's disease pathology
HY Wang et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2000)
Effect of membrane lipid composition on the conformational equilibria of the nicotinic acetylcholine receptor
JE Baenziger et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2000)
Nicotine binding in human striatum: Elevation in schizophrenia and reductions in dementia with Lewy bodies, Parkinson's disease and Alzheimer's disease and in relation to neuroleptic medication
JA Court et al.
NEUROSCIENCE (2000)
Amyloid peptide A beta(1-42) binds selectively and with picomolar affinity to alpha 7 nicotinic acetylcholine receptors
HY Wang et al.
JOURNAL OF NEUROCHEMISTRY (2000)
Cholinergic receptors: dual roles in transduction and plasticity
BJ Morley et al.
HEARING RESEARCH (2000)
Relationship between apoE genotype and CSF beta-amyloid (1-42) and tan in patients with probable and definite Alzheimer's disease
T Tapiola et al.
NEUROBIOLOGY OF AGING (2000)
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