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SCIENCE (2009)
Regulation of Histone Acetylation in the Nucleus by Sphingosine-1-Phosphate
Nitai C. Hait et al.
SCIENCE (2009)
Sphingosine-1-Phosphate Is a Key Regulator of Proliferation and Differentiation in Retina Photoreceptors
Gisela E. Miranda et al.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE (2009)
Wild-type levels of ceramide and ceramide-1-phosphate in the retina of ceramide kinase-like-deficient mice
Christine Graf et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2008)
Ceramide 1-phosphate stimulates macrophage activation of the PI3-kinase/PKB, JNK and proliferation through ERK1/2 pathways
Patricia Gangoiti et al.
CELLULAR SIGNALLING (2008)
The sphingolipid salvage pathway in ceramide metabolism and signaling
Kazuyuki Kitatani et al.
CELLULAR SIGNALLING (2008)
The Spinster Homolog, Two of Hearts, Is Required for Sphingosine 1-Phosphate Signaling in Zebrafish
Nick Osborne et al.
CURRENT BIOLOGY (2008)
Mechanisms of fibrogenesis
Tatiana Kisseleva et al.
EXPERIMENTAL BIOLOGY AND MEDICINE (2008)
Sphingosine-1-phosphate (S1P) is a novel fibrotic mediator in the eye
James S. Swaney et al.
EXPERIMENTAL EYE RESEARCH (2008)
Photoreceptor Cell Death Mechanisms in Inherited Retinal Degeneration
Javier Sancho-Pelluz et al.
MOLECULAR NEUROBIOLOGY (2008)
Principles of bioactive lipid signalling: lessons from sphingolipids
Yusuf A. Hannun et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2008)
Involvement of lysophosphatidic acid, sphingosine 1-phosphate and ceramide 1-phosphate in the metabolization of phosphatidic acid by lipid phosphate phosphatases in bovine rod outer segments
Susana J. Pasquare et al.
NEUROCHEMICAL RESEARCH (2008)
Diacylglyceride lipase activity in rod outer segments depends on the illumination state of the retina
S. J. Pasquare et al.
NEUROCHEMISTRY INTERNATIONAL (2008)
Cell-nonautonomous function of ceramidase in photoreceptor homeostasis
Jairaj K. Acharya et al.
NEURON (2008)
"Inside-Out" Signaling of Sphingosine-1-Phosphate: Therapeutic Targets
K. Takabe et al.
PHARMACOLOGICAL REVIEWS (2008)
Fibrotic disorders in the eye: Targets of gene therapy
Shizuya Saika et al.
PROGRESS IN RETINAL AND EYE RESEARCH (2008)
CERKL mutations and associated phenotypes in seven Spanish families with autosomal recessive retinitis pigmentosa
Almudena Avila-Fernandez et al.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE (2008)
Regulation and traffic of ceramide 1-phosphate produced by ceramide kinase - Comparative analysis to glucosylceramide and sphingomyelin
Alistair Boath et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2008)
Characterization of ceramide synthase 2 - Tissue distribution, substrate specificity, and inhibition by sphingosine 1-phosphate
Elad L. Laviad et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2008)
A role for S1P signalling in axon guidance in the Xenopus visual system
Laure Strochlic et al.
DEVELOPMENT (2008)
Critical role of ABCA1 transporter in sphingosine 1-phosphate release from astrocytes
Koichi Sato et al.
JOURNAL OF NEUROCHEMISTRY (2007)
A common founder mutation of CERKL underlies autosomal recessive retinal degeneration with early macular involvement among Yemenite Jews
Noa Auslender et al.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE (2007)
Sphingosine kinase 1 regulates differentiation of human and mouse lung fibroblasts mediated by TGF-β1
Yuko Kono et al.
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY (2007)
Essential role of sphingosine 1-phosphate receptor 2 in pathological angiogenesis of the mouse retina
Athanasia Skoura et al.
JOURNAL OF CLINICAL INVESTIGATION (2007)
Ceramide kinase uses ceramide provided by ceramide transport protein: localization to organelles of eicosanoid synthesis
Nadia F. Lamour et al.
JOURNAL OF LIPID RESEARCH (2007)
Sphingosine-1-phosphate lyase in immunity and cancer: silencing the siren
Padmavathi Bandhuvula et al.
TRENDS IN MOLECULAR MEDICINE (2007)
A potential role for PDGF-C in experimental and clinical proliferative vitreoretinopathy
Hetian Lei et al.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE (2007)
Ceramide as a TLR4 agonist;: a putative signalling intermediate between sphingolipid receptors for microbial ligands and TLR4
Hans Fischer et al.
CELLULAR MICROBIOLOGY (2007)
Ceramide kinase regulates growth and survival of A549 human lung adenocarcinoma cells
Poularal Mitra et al.
FEBS LETTERS (2007)
Sphingosine-induced apoptosis in rhabdomyosarcoma cell lines is dependent on pre-mitochondrial bax activation and post-mitochondrial caspases
Darren C. Phillips et al.
CANCER RESEARCH (2007)
The metabolism and function of sphingolipids and glycosphingolipids
S. Lahiri et al.
CELLULAR AND MOLECULAR LIFE SCIENCES (2007)
Common and unique mechanisms regulate fibrosis in various fibroproliferative diseases
Thomas A. Wynn
JOURNAL OF CLINICAL INVESTIGATION (2007)
Sphingosine kinases, sphingosine 1-phosphate, apoptosis and diseases
Nitai C. Hait et al.
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES (2006)
Diabetes alters sphingolipid metabolism in the retina - A potential mechanism of cell death in diabetic retinopathy
Todd E. Fox et al.
DIABETES (2006)
Role of ABCO in export of sphingosine-1-phosphate from mast cells
Poulami Mitra et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)
The multigenic sphingomyelin synthase family
Fikadu Geta Tafesse et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2006)
Ceramide is the key mediator of oxidative stress-induced apoptosis in retinal photoreceptor cells
Nuria Sanvicens et al.
JOURNAL OF NEUROCHEMISTRY (2006)
Transforming growth factor β2-induced myofibroblastic differentiation of human retinal pigment epithelial cells:: Regulation by extracellular matrix proteins and hepatocyte growth factor
Maria-Andreea Gamulescu et al.
EXPERIMENTAL EYE RESEARCH (2006)
Ceramide is a mediator of apoptosis in retina photoreceptors
OL German et al.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE (2006)
TGFβ pathobiology in the eye
S Saika
LABORATORY INVESTIGATION (2006)
The sphingosine and diacylglycerol kinase superfamily of signaling kinases: localization as a key to signaling function
Binks W. Wattenberg et al.
JOURNAL OF LIPID RESEARCH (2006)
Substrate specificity of human ceramide kinase
DS Wijesinghe et al.
JOURNAL OF LIPID RESEARCH (2005)
SphK1 and SphK2, sphingosine kinase isoenzymes with opposing functions in sphingolipid metabolism
M Maceyka et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
Dopamine release in PC12 cells is mediated by Ca2+-dependent production of ceramide via sphingomyelin pathway
HJ Jeon et al.
JOURNAL OF NEUROCHEMISTRY (2005)
Direct binding to ceramide activates protein kinase Cζ before the formation of a pro-apoptotic complex with PAR-4 in differentiating stem cells
GH Wang et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
Ceramide-1-phosphate promotes cell survival through activation of the phosphatidylinositol 3-kinase/protein kinase B pathway
A Gómez-Muñoz et al.
FEBS LETTERS (2005)
Laser induces apoptosis and ceramide production in human retinal pigment epithelial cells
A Barak et al.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE (2005)
A comprehensive classification system for lipids
E Fahy et al.
JOURNAL OF LIPID RESEARCH (2005)
Detailed characterization of the lipid composition of detergent-resistant membranes from photoreceptor rod outer segment membranes
RE Martin et al.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE (2005)
Characterization of a ceramide kinase-like protein
FR Bornancin et al.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS (2005)
Glomerular proliferation during early stages of diabetic nephropathy is associated with local increase of sphingosine-1-phosphate levels
K Geoffroy et al.
FEBS LETTERS (2005)
Ceramide-mediated macroautophagy involves inhibition of protein kinase B and up-regulation of beclin 1
F Scarlatti et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
Point-counterpoint of sphingosine 1-phosphate metabolism
JD Saba et al.
CIRCULATION RESEARCH (2004)
Ceramide 1-phosphate is a direct activator of cytosolic phospholipase A2
BJ Pettus et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
Acid and neutral sphingomyelinases: roles and mechanisms of regulation
N Marchesini et al.
BIOCHEMISTRY AND CELL BIOLOGY (2004)
Sphingosine contributes to glucocorticoid-induced apoptosis of thymocytes independently of the mitochondrial pathway
S Lépine et al.
JOURNAL OF IMMUNOLOGY (2004)
Differential transactivation of sphingosine-1-phosphate receptors modulates NGF-induced neurite extension
RE Toman et al.
JOURNAL OF CELL BIOLOGY (2004)
Biologically active sphingolipids in cancer pathogenesis and treatment
B Ogretmen et al.
NATURE REVIEWS CANCER (2004)
Sphingosine kinase 1 (SPHK1) is induced by transforming growth factor-β and mediates TIMP-1 up-regulation
M Yamanaka et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
Ceramide-induced apoptosis: Role of catalase and hepatocyte growth factor
R Kannan et al.
FREE RADICAL BIOLOGY AND MEDICINE (2004)
Mutation of CERKL, a novel human ceramide kinase gene, causes autosomal recessive retinitis pigmentosa (RP26)
M Tuson et al.
AMERICAN JOURNAL OF HUMAN GENETICS (2004)
Ceramide-1-phosphate blocks apoptosis through inhibition of acid sphingomyelinase in macrophages
A Gomez-Munoz et al.
JOURNAL OF LIPID RESEARCH (2004)
Sphingosine-dependent apoptosis: A unified concept based on multiple mechanisms operating in concert
E Suzuki et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)
Glycosphingolipidoses: Beyond the enzymatic defect
A Raas-Rothschild et al.
GLYCOCONJUGATE JOURNAL (2004)
The immunosuppressant FTY720 is phosphorylated by sphingosine kinase type 2
SW Paugh et al.
FEBS LETTERS (2003)
Raft ceramide in molecular medicine
E Gulbins et al.
ONCOGENE (2003)
Intracellular signal transduction pathways activated by ceramide and its metabolites
PP Ruvolo
PHARMACOLOGICAL RESEARCH (2003)
Cell cycle regulation in retinal progenitors by glia-derived neurotrophic factor and docosahexaenoic acid
MF Insua et al.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE (2003)
Modulating sphingolipid biosynthetic pathway rescues photoreceptor degeneration
U Acharya et al.
SCIENCE (2003)
Common signaling pathways link activation of murine PAR-1, LPA, and S1P receptors to proliferation of astrocytes
SD Sorensen et al.
MOLECULAR PHARMACOLOGY (2003)
Sphingosine in apoptosis signaling
O Cuvillier
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS (2002)
Sphingosine 1-phosphate triggers both apoptotic and survival signals for human hepatic myofibroblasts
J Davaille et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
Metabolic formation of ceramide-1-phosphate in cerebellar granule cells: Evidence for the phosphorylation of ceramide by different metabolic pathways
L Riboni et al.
NEUROCHEMICAL RESEARCH (2002)
Sphingosine 1-phosphate, a key cell signaling molecule.
S Spiegel et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
Sphingosine-1-phosphate receptors and the development of the vascular system
ML Allende et al.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS (2002)
Molecular mechanisms of ceramide-mediated CD95 clustering
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BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2001)
CD95 signaling via ceramide-rich membrane rafts
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JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
Enzymes of sphingolipid metabolism: From modular to integrative signaling
YA Hannun et al.
BIOCHEMISTRY (2001)
Sphingosine-1-phosphate phosphatases
SM Mandala
PROSTAGLANDINS & OTHER LIPID MEDIATORS (2001)
Sphingosine generation, cytochrome c release, and activation of caspase-7 in doxorubicin-induced apoptosis of MCF7 breast adenocarcinoma cells
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CELL DEATH AND DIFFERENTIATION (2001)
Physiology and pathophysiology of sphingolipid metabolism and signaling
A Huwiler et al.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS (2000)
Involvement of sphingosine in mitochondria-dependent Fas-induced apoptosis of type II Jurkat T cells
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JOURNAL OF BIOLOGICAL CHEMISTRY (2000)
Vectorial budding of vesicles by asymmetrical enzymatic formation of ceramide in giant liposomes
JM Holopainen et al.
BIOPHYSICAL JOURNAL (2000)
Ceramide-induced cell death in cultured rat retinal pigment epithelial cells
H Tomita et al.
TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE (2000)
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