Journal
ARCHIVES OF CARDIOVASCULAR DISEASES
Volume 109, Issue 10, Pages 550-561Publisher
ELSEVIER MASSON, CORP OFF
DOI: 10.1016/j.acvd.2016.03.004
Keywords
Pulmonary arterial hypertension; Right ventricular failure; Pathophysiological mechanisms; Pulmonary arterial hypertension experimental models
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Funding
- DOCnet [NORTE-01-0145-FEDER-000003]
- Norte Portugal Regional Operational Programme (NORTE), under the PORTUGAL Partnership Agreement, through the European Regional Development Fund (ERDF)
- Portuguese Foundation for Science and Technology (FCT) [FCOMP-01-0124-FEDER-028695, FCT-PTDC/DTP-FTO/0130/2012, SFRH/BD/87714/2012, SFRH/BD/96403/2013]
- Fundação para a Ciência e a Tecnologia [SFRH/BD/87714/2012, SFRH/BD/96403/2013] Funding Source: FCT
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Pulmonary arterial hypertension is a progressive syndrome based on diverse aetiologies, which is characterized by a persistent increase in pulmonary vascular resistance and overload of the right ventricle, leading to heart failure and death. Currently, none of the available treatments is able to cure pulmonary arterial hypertension; additional research is therefore needed to unravel the associated pathophysiological mechanisms. This review summarizes current knowledge related to this disorder, and the several experimental animal models that can mimic pulmonary arterial hypertension and are available for translational research. (C) 2016 Elsevier Masson SAS. All rights reserved.
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