Journal
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
Volume 611, Issue -, Pages 86-92Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.abb.2016.04.002
Keywords
Zinc; Mammary gland; Lactation; Proliferation; Differentiation; Secretion
Categories
Funding
- Huck Dissertation Research Award from the Huck Institute of Life Sciences at Penn State University
- [NIHD058614]
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Lactation provides many health benefits to the nursing infant and breastfeeding mother. In order to successfully breastfeed, the mammary gland must expand and differentiate to activate numerous processes that regulate milk production and secretion. This involves a complex series of molecular, biochemical and cellular events driven largely by lactogenic hormones. Recent advances implicate zinc as a critical modulator of mammary gland function. Here, we provide an overview of our current understanding of the role and regulation of zinc in promoting proliferation, differentiation and secretion in the mammary gland during lactation, and highlight critical gaps in knowledge. (C) 2016 Published by Elsevier Inc.
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