Journal
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
Volume 611, Issue -, Pages 134-141Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.abb.2016.04.016
Keywords
Drosophila; Zinc; Homeostasis; Gut; Neurodegeneration
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Funding
- National Science Foundation of China [30688001]
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Zinc is an essential micronutrient for all organisms. For multicellular organisms, zinc uptake, storage, distribution and export are tightly regulated at both cellular and organismal levels, to cope with the multiple requirements versus the toxicity of the metal ion. During the past decade, the fruit fly Drosophila melanogaster has become an important model organism for the elucidation of metazoan zinc homeostasis. This review describes our current knowledge of various zinc transporters in Drosophila, with an emphasis on the process of dietary zinc uptake in the fly. We also discuss how Drosophila was used as a model to facilitate our understanding of the role of zinc in neurodegenerative diseases. (C) 2016 Published by Elsevier Inc.
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