Journal
TRENDS IN IMMUNOLOGY
Volume 40, Issue 7, Pages 565-583Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.it.2019.04.012
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Funding
- Deutsche Forschungsgemeinschaft (DGF) [SFB1123 TP A6]
- Else Kroner-Fresenius-Stiftung (EKFS) [2016_A118]
- Israeli Cancer Research Foundation [01229/17]
- Israel Science Foundation [2122/16]
- Canadian Institutes of Health Research
- Associazione Italiana per la Ricerca sul Cancro (AIRC) [IG20339]
- Fondazione Cariverona
- European Cooperation in Science and Technology (COST) Action [BM1404]
- EU Framework Program Horizon 2020
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New evidence has challenged the outdated dogma that neutrophils are a homogeneous population of short-lived cells. Although neutrophil subpopulations with distinct functions have been reported under homeostatic and pathological conditions, a full understanding of neutrophil heterogeneity and plasticity is currently lacking. We review here current knowledge of neutrophil heterogeneity and diversity, highlighting the need for deep genomic, phenotypic, and functional profiling of the identified neutrophil subpopulations to determine whether these cells truly represent bona fide novel neutrophil subsets. We suggest that progress in understanding neutrophil heterogeneity will allow the identification of clinically relevant neutrophil subpopulations that may be used in the diagnosis of specific diseases and lead to the development of new therapeutic approaches.
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