Journal
TRENDS IN CELL BIOLOGY
Volume 29, Issue 10, Pages 835-847Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tcb.2019.07.001
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Funding
- European Regional Development Fund (ERDF) through the Operational Program for Competitiveness Factors (COMPETE) [PAC 'NETDIAMOND' POCI-01-0145-FEDER-016385, HealthyAging2020 CENTRO-01-0145-FEDER000012-N2323, POCI-01-0145-FEDER-007440, CENTRO-01-0145-FEDER-032179, CENTRO-01-0145-FEDER032414, FCTUID/NEU/04539/2013]
- Fundacao para a Ciencia e a Tecnologia (FCT) [PD/BD/106043/2015, PD/BD/52294/2013, SFRH/BD/115003/2016]
- Instituto de Salud Carlos III [PI16/00772, CPII16/00042]
- European Regional Development Fund (ERDF)
- Swiss National Science Foundation [10030_182573, 310030E_176050]
- Fundação para a Ciência e a Tecnologia [PD/BD/106043/2015, SFRH/BD/115003/2016, PD/BD/52294/2013] Funding Source: FCT
- Swiss National Science Foundation (SNF) [310030E_176050] Funding Source: Swiss National Science Foundation (SNF)
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Connexin43 (Cx43) is commonly associated with direct cell-cell communication through gap junctions (GJs). However, recent groundbreaking studies have challenged this dogma, implicating Cx43 in other biological processes, such as transcription, metabolism, autophagy, and ion channel trafficking. How Cx43 participates in these processes remains largely unknown, although its high turnover rate, capacity to bind to myriad proteins, and the discovery of truncated isoforms of Cx43, ascribe to this protein unanticipated roles in chief processes that require fine-tuned regulation. Accordingly, Cx43 can be regarded as a central integrative hub to which diverse cues converge to be processed in a concerted manner. In this review, we examine the noncanonical roles of Cx43 and discuss the implications of these functions in human diseases and future therapeutic strategies.
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