Journal
TRENDS IN BIOCHEMICAL SCIENCES
Volume 44, Issue 12, Pages 1022-1040Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tibs.2019.06.006
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Funding
- Campania Region (Programma Operativo FESR Campania 2014-2020) [Asse 1 - CUP B63D18000350007]
- Italian Ministry of University and Research (PRIN Programme 2015) [2015RNWJAM]
- EU (COST action) [CM1003]
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Metalloproteins are crucial for life. The mutual relationship between metal ions and proteins makes metalloproteins able to accomplish key processes in biological systems, often very difficult to reproduce with inorganic coordination compounds under mild conditions. Taking inspiration from nature, many efforts have been devoted to developing artificial molecules as metalloprotein mimics. We have witnessed an explosion of protein design strategies leading to designed metalloproteins, ranging from stable structures to functional molecules. This review illustrates the most recent results for inserting metalloprotein functions in designed and engineered protein scaffolds. The selected examples highlight the potential of different approaches for the construction of artificial molecules capable of simulating and even overcoming the features of natural metalloproteins.
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