Journal
TALANTA
Volume 199, Issue -, Pages 556-566Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.talanta.2019.02.066
Keywords
Aptamer; Portable sensor; Point-of-care diagnostics
Categories
Funding
- FRGS Grant [203/CIPPT/6711441]
- USM Research University Grant [1001.CIPPT.811317, 1001.CIPPT.8011095]
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Aptamers are nucleic acid-based molecular recognition elements that are specific and have high binding affinity against their respective targets. On account of their target recognition capacity, aptamers are widely utilized in a number of applications including diagnostics. This review aims to highlight the recent developments of aptasensors expedient for point-of-care (POC) diagnostics. Significant focus is given on the primary assay formats of aptamers such as fluorescence, electrochemical, surface plasmon resonance (SPR) and colorimetric assays. A potpourri of platforms such as paper-based device, lateral flow assay, portable electrodes, portable SPR and smart phones expedient for point-of-care (POC) diagnostics are discussed. Emphasis is also given on the technicalities and assay configurations associated with the sensors.
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