Journal
SYNTHETIC COMMUNICATIONS
Volume 49, Issue 20, Pages 2683-2695Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/00397911.2019.1639754
Keywords
2; 3-Dihydroquinazolin-4(1H)-ones; anthranilamide; chlorosulfonic acid; functionalized organo-nanocatalyst; magnetic nanocatalyst
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Funding
- DST-SERB [EEQ/2016/000646]
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A facile and highly efficient one-pot synthesis of 2,3-dihydroquinazolin-4(1H)-ones derivatives has been developed by the condensation of anthranilamide with aldehydes using sulfonic acid functionalized l-Proline@Fe3O4 nanoparticles as a catalyst. The advantages of this protocol are easy recovery and reusability of the catalyst besides simple work-up procedure and short reaction time. In addition, the anthelmintic activities of some selective compounds were investigated and it was found that 2-phenyl-2,3-dihydroquinazolin-4(1H)-one exhibited profound anthelmintic activity against two helminth models. [GRAPHICS]
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