Journal
SYNTHETIC COMMUNICATIONS
Volume 49, Issue 20, Pages 2642-2650Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/00397911.2019.1637894
Keywords
Alkylation; esterification; microwave; phosphonate; phosphonic acid; phosphonic monoester
Categories
Funding
- National Research, Development and Innovation Office [K119202]
- Gedeon Richter's Talentum Foundation
- Janos Bolyai Research Scholarship of the Hungarian Academy of Sciences [BO/00130/19/7]
Ask authors/readers for more resources
Possibilities for the mono- and diesterification of phenylphosphonic acid were evaluated considering the microwave(MW)-assisted direct esterification, and the alkylating esterification. It was found that regarding the monoesterification, the reaction with 15-fold alcohol excess in the presence of [bmim][BF4] additive utilizing MWs is superior than the approach by alkylation. At the same time, for the conversion of the monoester intermediate to the diester, the reaction with alkyl halides in the presence of triethylamine as the base, again under MW irradiation, was found to be the method of choice. Phosphonates with both identical and different alkoxy groups were made available. [GRAPHICS]
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available
Share Paper
