Journal
SYNTHETIC COMMUNICATIONS
Volume 49, Issue 19, Pages 2561-2571Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/00397911.2019.1634213
Keywords
Green chemistry; imidazo[1; 2-a]pyridine; Knoevenagel condensation; microwave irradiation; Suzuki-Miyaura cross-coupling
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Funding
- Centre National de la Recherche Scientifique (CNRS)
- Aix-Marseille University
- Houari Boumediene University of Sciences and Technology
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A series of imidazo[1,2-a]pyridinylpropenenitriles were synthesized via consecutive one-pot Suzuki-Miyaura and Knoevenagel reactions in water/ethanol mixture between imidazo[1,2-a]pyridine-2-carbaldehydes, arylboronic acids and malononitrile, methyl cyanoacetate or ethyl cyanoacetate. This environmental friendly procedure tolerates a wide range of boronic acids and affords a new substituted imidazo[1,2-a]pyridinyl propenenitriles in good yields under microwave irradiation. [GRAPHICS] .
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