Journal
SYNLETT
Volume 30, Issue 15, Pages 1738-1764Publisher
GEORG THIEME VERLAG KG
DOI: 10.1055/s-0037-1611875
Keywords
carbonyl-ene reactions; biaryl ligands; bis(oxazoline) ligands; Schiff base ligands; salen ligands; N,N '-dioxide ligands
Categories
Funding
- University of Kashan
Ask authors/readers for more resources
The carbonyl-ene reaction is one of the most well-known reactions for C-C bond formation. Based on frontier molecular orbitals (FMO), carbonyl-ene reactions occur between the highest occupied molecular orbital (HOMO) of the ene compound bearing an active hydrogen atom at the allylic center and the lowest unoccupied molecular orbital (LUMO) of the electron-deficient enophile, which is a carbonyl compound. A high activation barrier enforces the concerted ene reaction rather than a Diels-Alder reaction at high temperature. Employing a catalytic system can eliminate defects in the ene reaction, and chiral catalysts promote the reaction under mild conditions to produce optically active compounds. In this account, we highlight investigations on the effects of various classes of chiral ligands on intermolecular and intramolecular carbonyl-ene reactions.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available