4.1 Article

Future Research Goals in Immunotherapy

Journal

SURGICAL ONCOLOGY CLINICS OF NORTH AMERICA
Volume 28, Issue 3, Pages 505-+

Publisher

W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1016/j.soc.2019.02.006

Keywords

Biomarkers; Immunoprofiling; Combination immunotherapy; Seromics; T-cell agonists; Cancer vaccines

Ask authors/readers for more resources

In our opinion the most urgent needs to improve patient outcomes are: 1) a deeper ability to measure cancer immunobiology, and 2) increased availability of agents that, coupled with predictive biomarkers, will be used to tailor anti-cancer immunity. Tailoring effective immunotherapy will entail combinations of immunotherapeutics that augment priming of anti-cancer immunity, boost expansion of effector and memory cells of the T, B and NK lineage, amplify innate immunity and relieve checkpoint inhibition. Alternatives to inducing adaptive immunity to cancer include synthetic immunology that incorporate bi-specifics that target T cells to cancer or adoptive immunotherapy with gene-modified immune cells.

Authors

I am an author on this paper
Click your name to claim this paper and add it to your profile.

Reviews

Primary Rating

4.1
Not enough ratings

Secondary Ratings

Novelty
-
Significance
-
Scientific rigor
-
Rate this paper

Recommended

No Data Available
No Data Available