Journal
SMALL
Volume 15, Issue 36, Pages -Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/smll.201902309
Keywords
activated agents; breast cancer; contrast agents; fluorine magnetic resonance imaging; paramagnetic relaxation enhancement
Categories
Funding
- Australian Research Council [CE140100036, DP0987407, DP110104299, DP170104643, DP180101221, LE0775684, LE0668517, LE0882357, LE140100087, LE160100168]
- National Health and Medical Research Council [APP1157440, APP1021759]
- University of Queensland [UQECR1720289]
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F-19 magnetic resonance imaging (F-19 MRI) agents capable of being activated upon interactions with cancer triggers are attracting increasing attention, although challenges still remain for precise and specific detection of cancer tissues. In this study, a novel hybrid F-19 MRI agent for pH-sensitive detection of breast cancer tissues is reported, a composite system designed by conjugating a perfluoropolyether onto the surface of manganese-incorporated layered double hydroxide (Mn-LDH@PFPE) nanoparticles. The F-19 NMR/MRI signals from aqueous solutions of Mn-LDH@PFPE nanoparticles are quenched at pH 7.4, but turned on following a reduction in pH to below 6.5. This is due to partial dissolution of Mn2+ from the Mn-LDH nanoparticles and subsequent reduction in the effect of paramagnetic relaxation. Significantly, in vivo experiments reveal that an intense F-19 MR signal can be detected only in the breast tumor tissue after intravenous injection of Mn-LDH@PFPE nanoparticles due to such a specific activation. Thus pH-activated Mn-LDH@PFPE nanoparticles are a potential smart F-19 MRI agent for precise and specific detection of cancer diseases.
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