Journal
SMALL
Volume 15, Issue 34, Pages -Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/smll.201900968
Keywords
gold nanoclusters; prostate cancer; PSMA; radiosensitization; targeted radiotherapy
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Funding
- National Institute of Health [RO1 EB020353-03]
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For over a hundred years, X-rays have been a main component of the radiotherapeutic approaches to treat cancer. Yet, to date, no radiosensitizer has been developed to selectively target prostate cancer. Gold has excellent X-ray absorptivity and is used as a radiotherapy enhancing material. In this work, ultrasmall Au-25 nanoclusters (NCs) are developed for selective prostate cancer targeting, radiotherapy enhancement, and rapid clearance from the body. Targeted-Au-25 NCs are rapidly and selectively taken up by prostate cancer in vitro and in vivo and also have fast renal clearance. When combined with X-ray irradiation of the targeted cancer tissues, radiotherapy is significantly enhanced. The selective targeting and rapid clearance of the nanoclusters may allow reductions in radiation dose, decreasing exposure to healthy tissue and making them highly attractive for clinical translation.
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