Journal
SCIENCE TRANSLATIONAL MEDICINE
Volume 11, Issue 495, Pages -Publisher
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/scitranslmed.aaw2293
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Funding
- National Health and Medical Research Council (NHMRC) [APP1132373]
- Cancer Council Victoria project grant [APP1143517]
- National Breast Cancer Foundation Fellowship [ECF-17-005]
- NHMRC Senior Research Fellowship [APP1136680]
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The development of new cancer immunotherapies including checkpoint blockade and chimeric antigen receptor (CAR) T cell therapy has revolutionized cancer treatment. CART cells have shown tremendous success in certain B cell malignancies, resulting in U.S. Food and Drug Administration (FDA) approval of this approach for certain types of leukemia and lymphoma. However, response rates against solid cancer have been less successful to date. Approaches to modulate the immunosuppressive tumor microenvironment including targeting checkpoint pathways, modulating metabolic pathways, and generating cytokine-producing T cells have led to considerable enhancement of adoptive T cell immunotherapy, first in preclinical models and now in patients. This review provides a discussion of the most recent strategies to enhance the efficacy of CART cell antitumor responses in solid cancers.
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