Journal
SCIENCE AND TECHNOLOGY OF ADVANCED MATERIALS
Volume 20, Issue 1, Pages 746-757Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/14686996.2019.1629835
Keywords
Extracellular vesicles; exosomes; drug delivery system; biomarker; EV-based therapy
Categories
Funding
- Practical Research for Innovative Cancer Control [JP18ck0106366]
- Japan Agency for Medical Research and Development, AMED
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Extracellular vesicles (EVs) are small membraned vesicles and approximately 50-150 nm in diameter. Almost all of the type of cells releases the EVs and circulates in the body fluids. EVs contain multiple functional components, such as mRNAs, microRNAs (miRNAs), DNAs, and proteins, which can be transferred to the recipient cells, resulting in phenotypic changes. Recently, EV research has focused on their potential as a drug delivery vehicle and in targeted therapy against specific molecules. Moreover, some surface proteins are specific to particular diseases, and therefore, EVs also have promise as biomarkers. In this concise review, we summarize the latest research focused on EVs, which have the potential to become a promising drug delivery method, biomarker, and new therapeutic target for improving the outcomes of cancer patients. [GRAPHICS] .
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