Journal
SCIENCE
Volume 364, Issue 6444, Pages 971-+Publisher
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.aas9536
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Funding
- Swedish Research Council (Vetenskapsradet, VR) grant
- ERC Consolidator grant STEMMING-FROM-NERVE [N647844]
- Paradifference Foundation
- Bertil Hallsten Research Foundation
- CAREER award [NSF-14-532]
- NIH [R01HL131768]
- Swedish Research Council (Vetenskapsradet) [2016-03645]
- Knut and Alice Wallenberg Foundation
- Familjen Erling Perssons stiftelse
- Russian Science Foundation [18-75-10005]
- Swedish Research Council [2015-03387]
- Stiftelsen Riksbankens Jubileumsfond (Erik Ronnbergs fond stipend)
- RSF [16-15-10237]
- Russian Science Foundation [19-15-13023, 18-75-10005] Funding Source: Russian Science Foundation
- Swedish Research Council [2015-03387, 2016-03645] Funding Source: Swedish Research Council
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Neural crest cells are embryonic progenitors that generate numerous cell types in vertebrates. With single-cell analysis, we show that mouse trunk neural crest cells become biased toward neuronal lineages when they delaminate from the neural tube, whereas cranial neural crest cells acquire ectomesenchyme potential dependent on activation of the transcription factor Twist1. The choices that neural crest cells make to become sensory, glial, autonomic, or mesenchymal cells can be formalized as a series of sequential binary decisions. Each branch of the decision tree involves initial coactivation of bipotential properties followed by gradual shifts toward commitment. Competing fate programs are coactivated before cells acquire fate-specific phenotypic traits. Determination of a specific fate is achieved by increased synchronization of relevant programs and concurrent repression of competing fate programs.
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