Journal
SCIENCE
Volume 364, Issue 6446, Pages 1179-+Publisher
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.aaw7479
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Funding
- NIH [P01AI063302, R01AI142926, R21AI124143, P30 DK043351]
- Burroughs Wellcome Fund Investigator in the Pathogenesis of Infectious Disease award
- La Caixa foundation
- Crohn's and Colitis Foundation of America [252507]
- Center of Microbiome Informatics and Translation (MIT)
- John P. Stock Faculty Fellow award
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Intestinal adaptive immune responses influence host health, yet only a few intestinal bacteria species that induce cognate adaptive immune responses during homeostasis have been identified. Here, we show that Akkermansia muciniphila, an intestinal bacterium associated with systemic effects on host metabolism and PD-1 checkpoint immunotherapy, induces immunoglobulin G1 (IgG1) antibodies and antigen-specific T cell responses in mice. Unlike previously characterized mucosal responses, T cell responses to A. muciniphila are limited to T follicular helper cells in a gnotobiotic setting, without appreciable induction of other T helper fates or migration to the lamina propria. However, A. muciniphila-specific responses are context dependent and adopt other fates in conventional mice. These findings suggest that, during homeostasis, contextual signals influence T cell responses to the microbiota and modulate host immune function.
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