Journal
SCANDINAVIAN JOURNAL OF RHEUMATOLOGY
Volume 49, Issue 1, Pages 33-37Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/03009742.2019.1614213
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- Departement Hospitalo-Universitaire DHU 'FIRE'
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Objective: This study aimed to determine whether sCD163, a soluble macrophage marker up-regulated in numerous inflammatory disorders, is predictive of accelerated atherosclerosis associated with systemic lupus erythematosus (SLE). Methods: Carotid ultrasound was prospectively performed, at baseline and during follow-up, in 63 consecutive SLE patients asymptomatic for cardiovascular disease (CVD) and 18 volunteer health workers. Serum sCD163 level was determined at baseline using enzyme-linked immunosorbent assay. The primary outcome was the presence of a carotid plaque. Factors associated with carotid plaques were identified through multivariate analysis. Results: Despite a low risk for cardiovascular events according to Framingham score in both groups (2.1 +/- 3.8% in SLE vs 2.1 +/- 2.9% in controls; p = 0.416), ultrasound at baseline showed a carotid plaque in 23 SLE patients (36.5%) and two controls (11.1%) (p = 0.039). Multivariate analysis showed that SLE status increased the risk for carotid plaque by a factor of 9 (p = 0.017). In SLE patients, sCD163 level was high (483.7 +/- 260.8 ng/mL vs 282.1 +/- 97.5 ng/mL in controls; p < 0.001) and independently associated with carotid plaques, as assessed by stratification based on sCD163 quartile values (p = 0.009), receiver operating characteristics (p = 0.001), and multivariate analysis (p = 0.015). sCD163 at baseline was associated with the onset of carotid plaque during follow-up (3 +/- 1.4 years) in SLE patients who had no carotid plaque at the first evaluation (p = 0.041). Conclusion: sCD163 is associated with progressing carotid plaque in SLE and may be a useful biomarker for accelerated atherosclerosis in SLE patients at apparent low risk for CVD.
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