Journal
RUSSIAN JOURNAL OF GENERAL CHEMISTRY
Volume 89, Issue 5, Pages 1009-1014Publisher
MAIK NAUKA/INTERPERIODICA/SPRINGER
DOI: 10.1134/S1070363219050220
Keywords
NSC-710305; tazobactum; benzothiazole; 1; 2; 3-triazoles; anticancer activity
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A novel series of benzothiazole bearing 1,2,3-triazole derivatives 11a-11j are synthesized, and their structures are confirmed by H-1 and C-13 NMR, and mass spectral data. The synthesized compounds are tested for their anticancer activity towards human cancer cell lines including MCF-7 (breast), A549 (lung), Colo-205 (colon), and A2780 (ovarian) and demonstrate moderate to high activity. Among those, compounds 11b, 11c, 11d, 11e, 11f, and 11g are characterized by more potent activity than the standard drug.
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