Journal
RUSSIAN CHEMICAL BULLETIN
Volume 68, Issue 5, Pages 1052-1060Publisher
SPRINGER
DOI: 10.1007/s11172-019-2519-y
Keywords
berberine; berberrubine; sulfonate; cholesterol; hyperlipidemia; antifungal; activity; Cryptococcus neoformans; cytotoxicity
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Funding
- Wellcome Trust (UK)
- University of Queensland (Australia)
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The paper describes the synthesis of new tetrahydroberberrubine derivatives containing polyfl uorophenyl- or alkylsulfonate groups at the O(9) position as well as those containing or not containing a bromine atom at the C(12) position. In a model of acute Triton-induced hyperlipidemia, tetrahydroberberrubine 9-O-(heptafluoro-4'-toluene)sulfonate was shown to reduce the cholesterol level by 23.5%, which is comparable with the eff ect of Simvastatin. At a concentration of 32 g mL(-1), tetrahydroberberrubine 9-O-pentafluorobenzenesulfonate inhibits the growth of the fungus Cryptococcus neoformans by 81.3 +/- 3.5%.
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