Journal
RUSSIAN CHEMICAL BULLETIN
Volume 68, Issue 5, Pages 1000-1005Publisher
SPRINGER
DOI: 10.1007/s11172-019-2510-7
Keywords
1H-benzimidazoles; sterically hindered phenols; isobornylphenols; antioxidant activity; membrane-protective activity; red blood cells; oxidative hemolysis
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Funding
- Ministry of Science and Higher Education of the Russian Federation [AAAA-A18-118012490385-8, AAAA-A18-118011120004-5]
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A series of new 2-substituted-1H-benzimidazoles was synthesized on the basis of 4-hydroxybenzaldehydes. Their antioxidant properties were evaluated in the in vitro models and compared with those of known analogs. The structural specifi c features of the molecules responsible for the high antioxidant activity were revealed. Among tested derivatives, 2-substituted 1H-benzimidazole containing a phenol fragment with isobornyl and tert-butyl groups was found to have the greatest ability to protect biomolecules and cells under conditions of acute oxidative stress.
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