4.6 Review

Immunosuppressive B cells expressing PD-1/PD-L1 in solid tumors: a mini review

Journal

QJM-AN INTERNATIONAL JOURNAL OF MEDICINE
Volume 115, Issue 8, Pages 507-512

Publisher

OXFORD UNIV PRESS
DOI: 10.1093/qjmed/hcz162

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Funding

  1. National Natural Science Foundation of China [81872478]
  2. Key Project of Applied Basic Research of Sichuan Science and Technology Department [2018JY0550]

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This review discusses the expression of PD-1/PD-L1 on B cells and their immunosuppressive role in solid tumors, aiming to explore the potential for diagnostic tools and new therapies involving this unique group of cells.
Expression of programmed cell death-1 (PD-1/CD279) on T cells and the ligand of PD-1, programmed death ligand-1 (PD-L1) (CD274/B7-H1) on tumor cells or other immune cells, such as myeloid-derived suppressor cells, are important mechanisms to induce malignant immunosuppression. PD-1/PD-L1 expression on B-cell subsets, as well as their signaling and inhibitory functions in solid tumors will be discussed in this review with the focus on how B cells expressing PD-1/PD-L1 play immunosuppressive roles in tumor progression, aiming to figure out the potential for development of diagnostic tools and new therapies involving this unique group of cells.

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