Journal
PROTEOMICS
Volume 19, Issue 16, Pages -Publisher
WILEY
DOI: 10.1002/pmic.201800435
Keywords
antibiotic resistance; bacteria; biomarkers; targeted proteomics; virulence
Funding
- Flemish Ministry of Sciences (EWI, SOFI project IDIS)
- InBev-Baillet Latour Fund
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Mass spectrometry-based proteomics has been extensively used to map bacterial proteomes, which has led to a better understanding of the molecular mechanisms underlying bacterial infection and bacteria-host interactions. Quantitative proteomics using selected or parallel reaction monitoring is considered one of the most sensitive and specific quantitative MS-based approaches and has significantly advanced proteome studies of pathogenic bacteria. Here, recent applications of targeted proteomics for bacteria identification, biomarker discovery, and the characterization of bacterial virulence and antimicrobial resistance are reviewed among others. Results of such studies are expected to further contribute to improve the fight against the most common human pathogenic bacteria.
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