Journal
PROGRESS IN NEUROBIOLOGY
Volume 181, Issue -, Pages -Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.pneurobio.2019.101660
Keywords
Mitochondrial degradation; Neurodegeneration; Parkinson's disease; Alpha-synuclein; Alzheimer's disease; Amyloid beta; SOD1; Huntingtin; PreP; HtrA2; Omi
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Funding
- Deutsche Forschungsgemeinschaft (DFG) [LA 3609/2-1]
- Wellcome Trust
- UK Medical Research Council (MRC)
- Alzheimer Research UK (ARUK)
- Infinitus China Ltd.
- MRC [MR/K02292X/1, G0902243] Funding Source: UKRI
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This perspective article outlines mechanisms of mitochondrial import and protein degradation and how these have been linked to alpha-synuclein and Amyloid beta (A beta) homeostasis. Our aim is to underpin and stimulate the debate on the recent conception of mitochondria as protein degrading organelles, which suggests that mitochondria are more directly involved in neurodegenerative diseases than previously assumed.
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