Journal
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
Volume 93, Issue -, Pages 77-83Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.pnpbp.2019.03.008
Keywords
Obsessive-compulsive disorder; Network homogeneity; Default mode network; Resting-state
Funding
- National Key R&D Program of China [2016YFC1307100]
- National Natural Science Foundation of China [81,571,310, 81,771,447]
- Heilongjiang Natural Science Foundation of China [H2016100]
- Project of Qigihar Academy of Medical Sciences, China [QMSI2017B-08]
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Background: Default-mode network (DMN) plays a key role in the pathophysiology of obsessive - compulsive disorder (OCD). However, the network homogeneity (NH) of DMN in OCD remains equivocal. Objective: This study aimed to investigate abnormalities in the NH of the DMN at rest and the correlation between the NH of DMN and clinical variables in patients with OCD. Methods: This study used the independent component analysis and unbiased hypothesis-driven NH method to analyze the resting-state functional magnetic resonance imaging data of 40 drug-naive patients with OCD and 40 age-, gender-, and education-matched healthy controls (HCs). Results: Patients with OCD exhibited decreased NH values in the left ventral medial prefrontal cortex and bilateral posterior cingulate cortex (PCC)/precuneus (PCu) compared with HCs. Furthermore, analyses of receiver operating characteristic curves indicated that the decreased NH values in the right PCC/PCu may be used as a candidate neuroimaging marker to distinguish patients with OCD from HCs. Conclusion: These findings contribute new evidence of the participation of the altered NH of the DMN in the pathophysiology of OCD.
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