Related references
Note: Only part of the references are listed.Targeting adenylate-forming enzymes with designed sulfonyladenosine inhibitors
Michaelyn C. Lux et al.
JOURNAL OF ANTIBIOTICS (2019)
Atg7 Activates an Autophagy-Essential Ubiquitin-like Protein Atg8 through Multi-Step Recognition
Masaya Yamaguchi et al.
JOURNAL OF MOLECULAR BIOLOGY (2018)
A small-molecule inhibitor of the ubiquitin activating enzyme for cancer treatment
Marc L. Hyer et al.
NATURE MEDICINE (2018)
Crystal structure of a human ubiquitin E1-ubiquitin complex reveals conserved functional elements essential for activity
Zongyang Lv et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2018)
Molecular mechanism of a covalent allosteric inhibitor of SUMO E1 activating enzyme
Zongyang Lv et al.
NATURE COMMUNICATIONS (2018)
Ubiquitin-like Protein Conjugation: Structures, Chemistry, and Mechanism
Laurent Cappadocia et al.
CHEMICAL REVIEWS (2018)
Domain alternation and active site remodeling are conserved structural features of ubiquitin E1
Zongyang Lv et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2017)
S-pombe Uba1-Ubc15 Structure Reveals a Novel Regulatory Mechanism of Ubiquitin E2 Activity
Zongyang Lv et al.
MOLECULAR CELL (2017)
Probing the roles of SUMOylation in cancer cell biology by using a selective SAE inhibitor
Xingyue He et al.
NATURE CHEMICAL BIOLOGY (2017)
Dissecting the Specificity of Adenosyl Sulfamate Inhibitors Targeting the Ubiquitin-Activating Enzyme
Mohit Misra et al.
STRUCTURE (2017)
Drugging the undruggables: exploring the ubiquitin system for drug development
Xiaodong Huang et al.
CELL RESEARCH (2016)
Structural insights into the catalysis and regulation of E3 ubiquitin ligases
Lori Buetow et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2016)
Trans- Binding Mechanism of Ubiquitin- like Protein Activation Revealed by a UBA5-UFM1 Complex
Walaa Oweis et al.
CELL REPORTS (2016)
Structural and Functional Insights to Ubiquitin-Like Protein Conjugation
Frederick C. Streich et al.
ANNUAL REVIEW OF BIOPHYSICS, VOL 43 (2014)
Structure of the ubiquitin-activating enzyme loaded with two ubiquitin molecules
Antje Schaefer et al.
ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY (2014)
Structure of a Ubiquitin E1-E2 Complex: Insights to E1-E2 Thioester Transfer
Shaun K. Olsen et al.
MOLECULAR CELL (2013)
Structure of PA1221, a Nonribosomal Peptide Synthetase Containing Adenylation and Peptidyl Carrier Protein Domains
Carter A. Mitchell et al.
BIOCHEMISTRY (2012)
Structural and Functional Investigation of the Intermolecular Interaction between NRPS Adenylation and Carrier Protein Domains
Jesse A. Sundlov et al.
CHEMISTRY & BIOLOGY (2012)
Ubiquitin-like modifiers
Asad M. Taherbhoy et al.
LYSINE-BASED POST-TRANSLATIONAL MODIFICATION OF PROTEINS (2012)
E1-E2 Interactions in Ubiquitin and Nedd8 Ligation Pathways
Zeynep Tokgoez et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2012)
Noncanonical recognition and UBL loading of distinct E2s by autophagy-essential Atg7
Masaya Yamaguchi et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2012)
Noncanonical E2 recruitment by the autophagy E1 revealed by Atg7-Atg3 and Atg7-Atg10 structures
Stephen E. Kaiser et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2012)
Ubiquitination of Substrates by Esterification
Xiaoli Wang et al.
TRAFFIC (2012)
Atg8 Transfer from Atg7 to Atg3: A Distinctive E1-E2 Architecture and Mechanism in the Autophagy Pathway
Asad M. Taherbhoy et al.
MOLECULAR CELL (2011)
Structural Basis of Atg8 Activation by a Homodimeric E1, Atg7
Nobuo N. Noda et al.
MOLECULAR CELL (2011)
UBCH7 reactivity profile reveals parkin and HHARI to be RING/HECT hybrids
Dawn M. Wenzel et al.
NATURE (2011)
Ubiquitin-like protein conjugation and the ubiquitin-proteasome system as drug targets
Lynn Bedford et al.
NATURE REVIEWS DRUG DISCOVERY (2011)
Insights into noncanonical E1 enzyme activation from the structure of autophagic E1 Atg7 with Atg8
Seung Beom Hong et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2011)
Features and development of Coot
P. Emsley et al.
ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY (2010)
PHENIX: a comprehensive Python-based system for macromolecular structure solution
Paul D. Adams et al.
ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY (2010)
The family of ubiquitin-conjugating enzymes (E2s): deciding between life and death of proteins
Sjoerd J. L. van Wijk et al.
FASEB JOURNAL (2010)
Crystal Structure of the Human Ubiquitin-activating Enzyme 5 (UBA5) Bound to ATP MECHANISTIC INSIGHTS INTO A MINIMALISTIC E1 ENZYME
John-Paul Bacik et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2010)
Designed Semisynthetic Protein Inhibitors of Ub/Ubl E1 Activating Enzymes
Xuequan Lu et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2010)
STRUCTURAL BIOLOGY Transformative encounters
Brenda A. Schulman et al.
NATURE (2010)
Active site remodelling accompanies thioester bond formation in the SUMO E1
Shaun K. Olsen et al.
NATURE (2010)
The SUMO pathway: emerging mechanisms that shape specificity, conjugation and recognition
Jaclyn R. Gareau et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2010)
Conformational Dynamics in the Acyl-CoA Synthetases, Adenylation Domains of Non-ribosomal Peptide Synthetases, and Firefly Luciferase
Andrew M. Gulick
ACS CHEMICAL BIOLOGY (2009)
An inhibitor of NEDD8-activating enzyme as a new approach to treat cancer
Teresa A. Soucy et al.
NATURE (2009)
Ubiquitin-like protein activation by E1 enzymes: the apex for downstream signalling pathways
Brenda A. Schulman et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2009)
Structural characterization of a 140° domain movement in the two-step reaction catalyzed by 4-Chlorobenzoate: CoA ligase
Albert S. Reger et al.
BIOCHEMISTRY (2008)
Structural insights into E1-catalyzed ubiquitin activation and transfer to conjugating enzymes
Imsang Lee et al.
CELL (2008)
Identification of conjugation specificity determinants unmasks vestigial preference for ubiquitin within the NEDD8 E2
Danny T. Huang et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2008)
Phaser crystallographic software
Airlie J. McCoy et al.
JOURNAL OF APPLIED CRYSTALLOGRAPHY (2007)
Basis for a ubiquitin-like protein thioester switch toggling E1-E2 affinity
Danny T. Huang et al.
NATURE (2007)
Version 1.2 of the Crystallography and NMR system
Axel T. Brunger
NATURE PROTOCOLS (2007)
Drug discovery in the ubiquitin-proteasome system
Grzegorz Nalepa et al.
NATURE REVIEWS DRUG DISCOVERY (2006)
Pleiotropic effects of ATP•Mg2+ binding in the catalytic cycle of ubiquitin-activating enzyme
Zeynep Tokgoz et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2006)
Structure of the Escherichia coli ThiS-ThIF complex, a key component of the sulfur transfer system in thiamin biosynthesis
C Lehmann et al.
BIOCHEMISTRY (2006)
Structures of the SUMO E1 provide mechanistic insights into SUMO activation and E2 recruitment to E1
LM Lois et al.
EMBO JOURNAL (2005)
A unique E1-E2 interaction required for optimal conjugation of the ubiquitin-like protein NEDD8
DT Huang et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2004)
Insights into the ubiquitin transfer cascade from the structure of the activating enzyme for NEDD8
H Walden et al.
NATURE (2003)
Protein interactions within the N-end rule ubiquitin ligation pathway
TJ Siepmann et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
The structure of the APPBP1-UBA3-NEDD8-ATP complex reveals the basis for selective ubiquitin-like protein activation by an E1
H Walden et al.
MOLECULAR CELL (2003)
Mechanism of ubiquitin activation revealed by the structure of a bacterial MoeB-MoaD complex
MW Lake et al.
NATURE (2001)
A novel active site-directed probe specific for deubiquitylating enzymes reveals proteasome association of USP14
A Borodovsky et al.
EMBO JOURNAL (2001)
Ulp1-SUMO crystal structure and genetic analysis reveal conserved interactions and a regulatory element essential for cell growth in yeast
E Mossessova et al.
MOLECULAR CELL (2000)
Share Paper
