Journal
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Volume 116, Issue 30, Pages 15068-15073Publisher
NATL ACAD SCIENCES
DOI: 10.1073/pnas.1900038116
Keywords
Schwann cell precursors; mesenchymal cells; cartilage; bone; glia
Categories
Funding
- Swedish Research Council [2016-02835, 2018-02713, 2015-02623, 2015-03387]
- Karolinska Institute
- Strategiska Forskningsomradet Stem/Regen Junior Grant
- Russian Science Foundation [18-75-10005]
- European Molecular Biology Organization
- Stiftelsen Frimurare Barnhuset I Stockholm
- Russian Foundation for Basic Research Grant [19-29-04035]
- Chinese Scholarship Council
- Svenska Sallskapet for Medicinsk Forskning fellowship
- Novo Nordisk Foundation (Postdoc fellowship in Endocrinology and Metabolism at International Elite Environments) [NNF17OC0026874]
- Stiftelsen Riksbankens Jubileumsfond
- Canadian Institutes of Health Research
- Hospital for Sick Children Restracomp
- Ontario Institute for Regenerative Medicine
- Vinnova [2018-02713] Funding Source: Vinnova
- Russian Science Foundation [18-75-10005] Funding Source: Russian Science Foundation
- Swedish Research Council [2015-02623, 2016-02835, 2018-02713, 2015-03387] Funding Source: Swedish Research Council
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Immature multipotent embryonic peripheral glial cells, the Schwann cell precursors (SCPs), differentiate into melanocytes, parasympathetic neurons, chromaffin cells, and dental mesenchymal populations. Here, genetic lineage tracing revealed that, during murine embryonic development, some SCPs detach from nerve fibers to become mesenchymal cells, which differentiate further into chondrocytes and mature osteocytes. This occurred only during embryonic development, producing numerous craniofacial and trunk skeletal elements, without contributing to development of the appendicular skeleton. Formation of chondrocytes from SCPs also occurred in zebrafish, indicating evolutionary conservation. Our findings reveal multipotency of SCPs, providing a developmental link between the nervous system and skeleton.
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