Journal
POLYHEDRON
Volume 166, Issue -, Pages 146-152Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.poly.2019.03.051
Keywords
Reduced Schiff base; Zinc complex; Cobalt complex; Nickel complex; Urease inhibitory activity
Categories
Funding
- Education Office of Liaoning Province [LF201783611]
- Undergraduate Innovation and Entrepreneurship Training Program of Liaoning Province
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A series of new Zn-II, co(II/III) and Ni-II complexes derived from reduced Schiff base 6,6'-((propane-1,3-diylbis (azanediyl))bis(methylene))bis(2-ethoxyphenol) (H2L), [Zn3L2(N-3)(2)] (1), (CO2L)(N-3)(2)(CH3COO)]center dot CH3OH (2) and [Ni(HL)(OH2)(CH3OH)]center dot ClO4 (3), were prepared and characterized by physico-chemical methods. Crystal structures of the complexes were determined by single crystal X-ray diffraction. Complex 1 is a trinuclear zinc(II) compound. Complex 2 is a dinuclear cobalt(II/III) compound. Complex 3 is a mononuclear nickel(II) compound. The cobalt complex and the nickel complex have effective urease inhibitory activities, with IC50 values of 19.8 and 11.6 mu mol.L-1, respectively. However, the zinc complex 1 has no such activity. Molecular docking study of complexes 2 and 3 with the active center of Jack bean urease was studied. (C) 2019 Elsevier Ltd. All rights reserved.
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