Journal
PHYSIOLOGY & BEHAVIOR
Volume 206, Issue -, Pages 185-190Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.physbeh.2019.04.007
Keywords
Anorexia nervosa; Motivation; Cornet; Anxiety; Brain
Categories
Funding
- NIMH [MH096777, MH103436]
- NIH [T32HD041697]
- NIH/NCATSColorado CTSA grant [TL1 TR001081]
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Anorexia nervosa is a severe psychiatric illness with high mortality. Brain imaging recearch has indicated altered reward circuits in the disorder. Here we propose a disease model for anorexia nervosa, supported by recent studies, that integrates psychological and biological factors. In that model, we propose that there is a conflict between the conscious motivation to restrict food, and a body-homeostasis driven motivation to approach food in response to weight loss. These opposing motivations trigger anxiety, which maintains the vicious cycle of ongoing energy restriction and weight loss.
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