Journal
PHARMACOLOGY & THERAPEUTICS
Volume 203, Issue -, Pages -Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.pharmthera.2019.07.001
Keywords
RNA-binding proteins; RNA-binding domains; Cancer therapeutics; Small molecules; siRNA; Peptide; Aptamer
Categories
Funding
- [RO1 CA224433]
- [RO1 CA081237]
- [RO1 CA195828]
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RNA-binding proteins (RBPs) play a critical role in the regulation of various RNA processes, including splicing, cleavage and polyadenylation, transport, translation and degradation of coding RNAs, non-coding RNAs and microRNAs. Recent studies indicate that RBPs not only play an instrumental role in normal cellular processes but have also emerged as major players in the development and spread of cancer. Herein, we review the current knowledge about RNA binding proteins and their role in tumorigenesis as well as the potential to target RBPs for cancer therapeutics. (C) 2019 Elsevier Inc. All rights reserved.
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