Journal
PAIN MEDICINE
Volume 21, Issue 1, Pages 125-137Publisher
OXFORD UNIV PRESS
DOI: 10.1093/pm/pnz112
Keywords
Neuropathic-Like Pain; Knee Osteoarthritis; painDETECT; Pain Modulation
Categories
Funding
- National Institutes of Health (NIH) [R37AG033906, T32AG049673, K22NS102334, R01AG054370, K23AR062099]
- NIH Center for Advancing Translational Sciences [UL1TR001427, UL1TR001417]
- NIH [K99AG052642, TL1TR001418, R25CA090314]
- UF McKnight Brain Institute Career Enhancement Award
Ask authors/readers for more resources
Objective. To characterize neuropathic-like pain among individuals with or at risk for knee osteoarthritis. Subjects. One N hundred eighty-four individuals who self-identified as non-Hispanic black or non-Hispanic white and presented with unilateral or bilateral knee pain. Design. Neuropathic-like pain was assessed using the painDETECT, and those with high vs low neuropathic-like pain were compared on clinical pain, psychological symptoms, physical function, and quantitative sensory testing. Analyses were unadjusted, partially and fully adjusted for relevant covariates. Results. Thirty-two (17.4%) participants reported experiencing neuropathic-like pain features above the painDETECT clinical cut-score. The neuropathic-like pain group reported significantly greater pain severity on all measures of clinical pain and higher levels of psychological symptoms when fully adjusted for covariates, but no differences emerged for disability and lower extremity function. The neuropathic-like pain group also reported greater overall heat pain ratings during the heat pain threshold and increased temporal summation of heat pain in the fully adjusted model. Additionally, those with neuropathic-like pain symptoms reported greater painful after-sensations following heat pain temporal summation in all analyses. No significant group differences in pressure pain threshold emerged at any of the testing sites. In contrast, temporal summation of mechanical pain was significantly greater at both the index knee and the ipsilateral hand for the neuropathic-like pain group in all analyses. Conclusions. Participants with or at risk for knee osteoarthritis who reported high neuropathic-like pain experienced significantly greater clinical pain and increased heat and mechanical temporal summation at the index knee and other body sites tested, suggesting central sensitization.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available