4.8 Article

Cu-Catalyzed Cross-Dehydrogenative Coupling of Heteroaryl C(sp2)-H and Tertiary C(sp3)-H Bonds for the Construction of All-Carbon Triaryl Quaternary Centers

Journal

ORGANIC LETTERS
Volume 21, Issue 13, Pages 5152-5156

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.9b01755

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Funding

  1. Natural Science Foundation of China [21676076, 21878071]
  2. Hu-Xiang High Talent in Hunan Province [2018RS3042]
  3. Recruitment Program for Foreign Experts of China [WQ20164300353]

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A Cu-catalyzed protocol for cross-dehydrogenative coupling of benzofuranones with quinolines, indoles, carbazoles, and thiophene, which furnishes highly functionalized 3,3-diaryl benzofuranones bearing a three aryl quaternary carbon center at the C3 position in good yields, has been developed. A radical mechanism is proposed.

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