4.8 Article

Photocontrolled Single-/Dual-Site Alternative Fluorescence Probes Distinguishing Detection of H2S/SO2 in Vivo

Journal

ORGANIC LETTERS
Volume 21, Issue 13, Pages 5277-5280

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.9b01879

Keywords

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Funding

  1. National Natural Science Foundation of China [21775096, 21672131, 21705102]
  2. Shanxi Province 1331 project key innovation team construction plan cultivation team [2018-CT-1]
  3. Shanxi Province Foundation for Returness [2017-026]
  4. Shanxi Province Science Foundation for Youths [201701D221061]
  5. Shanxi Collaborative Innovation Center of High Value-added Utilization of Coal-related Wastes, China Institute for Radiation Production and Scientific Instrument Center of Shanxi University [201512]

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Herein, a novel fluorescent probe by integrating 4-azide-1,8-naphthalic anhydride and spiropyran was obtained. NT-N-3-SP was capable of specifically monitoring H2S by azide reduced. Upon irradiation by alternate ultraviolet and visible light, both the structure and emission of spiropyran moiety in NT-N-3-SP can be reversibly tuned. Importantly, the alternation will be interrupted in the presence of SO2. Additionally, NT-N-3-SP was successfully used for detection of H2S/SO2 in cells and mice.

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