Journal
ORGANIC LETTERS
Volume 21, Issue 16, Pages 6361-6365Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.9b02243
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Funding
- National Natural Science Foundation of China [21702237, 21272004]
- Start-up Research Fund of Anhui Normal University
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Direct construction of N-C axial chirality via Pd-catalyzed atroposelective C-H olefination of N-arylindoles is reported. The crucial role of chiral amino acid as a cocatalyst in the regio- and stereocontrol has been disclosed. In this reaction, a wide range of arylindoles and functional alkenes could be well tolerated. Moreover, the practicality and synthetic value of this process were demonstrated by the divers and simple transformations of the products.
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