Journal
ORGANIC LETTERS
Volume 21, Issue 14, Pages 5737-5741Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.9b02139
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Funding
- Guangdong Innovative and Entrepreneurial Research Team Program [2016ZT06Y337]
- National Natural Science Foundation of China [21801255]
- National Science & Technology Major Project [2018ZX09711002-006]
- Natural Science Foundation of Guangdong Province [2018A030310141]
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Developing an efficient and highly enantioselective protocol to access homopropargyl amines is of high interest to the synthetic community and also remains a formidable challenge for organic chemists. Here, we present integrated Rh-2(OAc)(4)- and BINOL-derived chiral phosphoric acid cooperatively catalyzed three-component reactions of alkynyldiazoacetates, imines with various nucleophiles including alcohols, indoles, and N,N-disubstituted anilines, affording the corresponding homopropargyl amines containing two vicinal chiral centers in satisfactory yields with high to excellent diastereo- and enantioselectivities.
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