Journal
ORGANIC LETTERS
Volume 21, Issue 16, Pages 6539-6542Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.9b02466
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Funding
- National Key R&D Program of China [2018YFC0311002]
- NSFC [81573306, 41876148]
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Talaromyolides A-D (1-4) and talaromytin (5) were isolated from a marine fungus Talaromyces sp. CX11. Their structures were unambiguously determined by nuclear magnetic resonance (NMR), mass spectrometry, X-ray crystallography experiments, and time-dependent density functional theory electronic circular dichroism calculations. Talaromyolides A and D represent two novel carbon skeletons. Talaromytin exhibits two slowly interconverting conformers in DMSO-d(6) and CH3OH-d(4) that were studied by temperature-dependent NMR experiments. Talaromyolide D exhibits potent antiviral activity against pseudorabies virus (PRV) with a CC50 value of 3.35 mu M.
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