Journal
ORGANIC LETTERS
Volume 21, Issue 16, Pages 6447-6451Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.9b02342
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Funding
- NIH-NIGMS [R01-GM117016]
- California Tobacco-Related Disease Research Program [28DT-0006]
- University of California, Los Angeles
- NSF [CHE-1048804]
- NIH NCRR [S10RR025631]
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An experimental protocol to achieve the Meerwein-Ponndorf-Verley (MPV) reduction of ketones under mildly basic conditions is reported. The transformation is tolerant of a range of ketone substrates, including O- and S-containing heterocycles, is scalable, and shows potential to be used as a platform to access enantioenriched products. These studies provide a general method for achieving the reduction of ketones under mildly basic conditions and offer an alternative protocol to more well-known AI-based MPV reduction conditions.
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