Journal
ORGANIC LETTERS
Volume 21, Issue 12, Pages 4698-4702Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.9b01578
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Funding
- National Natural Science Foundation of China [21871071]
- Major Scientific and Technological Innovation Project of Zhejiang [2019C01081]
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The first example of oxidative C-H fluoroalkoxylation of quinoxalinones with fluoroalkyl alcohols under transition-metal and solvent-free conditions is described. This approach provides the synthesis of fluoroalkoxylated quinoxaline derivatives with good to excellent yields under mild reactions conditions. This method can also be extended to the facile and efficient synthesis of histamine-4 receptor.
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