Journal
ORGANIC LETTERS
Volume 21, Issue 12, Pages 4424-4427Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.9b01064
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Funding
- Natural Science Foundation of China [21572264, 21871293]
- Chinese Universities Scientific Fund [2018TC052, 2018TC055, 2019TC085]
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A palladium-catalyzed asymmetric tandem [3+2] cycloaddition/allylation of methylene-trimethylenemethane is presented, providing the functionalized chiral hexahydropyrazolo[5,1-a]isoquinoline derivatives in high yields with good to excellent enantioselectivities and moderate to good E:Z ratios. In the one-pot sequential tandem reactions/hydroxylation, (E)-allylic alcohol products were obtained in good yields with excellent enantioselectivities.
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