Journal
ORGANIC LETTERS
Volume 21, Issue 12, Pages 4480-4485Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.9b01329
Keywords
-
Categories
Funding
- NSFC [21632003, 21871116, 21572087]
- Key Program of Gansu Province [17ZD2GC011]
- 111 Program from the MOE of P. R China
Ask authors/readers for more resources
A visible-light-promoted metal-free alkylheteroarylation of unactivated olefins was developed by using readily available ketones/esters as the alkyl radical source. With this strategy, both linear and cyclic ketones/esters could be conveniently converted to corresponding alpha-carbonyl alkyl radical species by using commonly found diacylperoxide (LPO) as the hydrogen atom transfer reagent, and heteroaryl-containing 1,7-carbonyl compounds were synthesized via distal heteroaryl ipso migration in good to excellent yields with high functional group tolerance and a broad substrate scope. In addition, this approach was also amenable to C-H functionalization of acetonitrile, dichloromethane, 1,2-dichloroethane, and chloroform.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available