Journal
ONCOGENE
Volume 38, Issue 35, Pages 6283-6300Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/s41388-019-0875-6
Keywords
-
Funding
- CNRS
- ARC foundation [PJA 20151203185]
- Human Frontier Science Program (HFSP) [RPG0040/2012]
- European Research Council under the European Union's Seventh Framework Program (FP7/2007-2013)/ERC grant [617233]
- Agence Nationale de la Recherche [ANR 2010 Blan1515]
- NUS-USPC exchange program
- HFSP [RPG0040/2012]
- Fondation pour la Recherche Medicale and Labex WhoAmI
- Region Ile de France [E539]
- Ligue contre le Cancer [R03/75-79]
- Fondation pour la Recherche Medicale [FDT20150532600]
- Association pour la Recherche contre le Cancer (Fondation ARC) [P2009 CDD POST-DOC]
- DDF by North West Cancer
- Cancer and Polio Research Fund
- ImagoSeine core facility of the Institut Jacques Monod, member of IBiSA and France-BioImaging [ANR-10-INBS-04]
Ask authors/readers for more resources
N-cadherin adhesion has been reported to enhance cancer and neuronal cell migration either by mediating actomyosin-based force transduction or initiating fibroblast growth factor receptor (FGFR)-dependent biochemical signalling. Here we show that FGFR1 reduces N-cadherin-mediated cell migration. Both proteins are co-stabilised at cell-cell contacts through direct interaction. As a consequence, cell adhesion is strengthened, limiting the migration of cells on N-cadherin. Both the inhibition of migration and the stabilisation of cell adhesions require the FGFR activity stimulated by N-cadherin engagement. FGFR1 stabilises N-cadherin at the cell membrane through a pathway involving Src and p120. Moreover, FGFR1 stimulates the anchoring of N-cadherin to actin. We found that the migratory behaviour of cells depends on an optimum balance between FGFR-regulated N-cadherin adhesion and actin dynamics Based on these findings we propose a positive feed-back loop between N-cadherin and FGFR at adhesion sites limiting N-cadherin-based single-cell migration.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available