Journal
OBESITY
Volume 27, Issue 8, Pages 1244-1254Publisher
WILEY
DOI: 10.1002/oby.22518
Keywords
-
Categories
Funding
- NCATS NIH HHS [KL2 TR001419] Funding Source: Medline
- NIDDK NIH HHS [P30 DK079626, P30 DK056336, P30 DK072476] Funding Source: Medline
- NIGMS NIH HHS [U54 GM104940] Funding Source: Medline
Ask authors/readers for more resources
Objective Eating earlier in the daytime to align with circadian rhythms in metabolism enhances weight loss. However, it is unknown whether these benefits are mediated through increased energy expenditure or decreased food intake. Therefore, this study performed the first randomized trial to determine how meal timing affects 24-hour energy metabolism when food intake and meal frequency are matched. Methods Eleven adults with overweight practiced both early time-restricted feeding (eTRF) (eating from 8 am to 2 pm) and a control schedule (eating from 8 am to 8 pm) for 4 days each. On the fourth day, 24-hour energy expenditure and substrate oxidation were measured by whole-room indirect calorimetry, in conjunction with appetite and metabolic hormones. Results eTRF did not affect 24-hour energy expenditure (Delta = 10 +/- 16 kcal/d; P = 0.55). Despite the longer daily fast (intermittent fasting), eTRF decreased mean ghrelin levels by 32 +/- 10 pg/mL (P = 0.006), made hunger more even-keeled (P = 0.006), and tended to increase fullness (P = 0.06-0.10) and decrease the desire to eat (P = 0.08). eTRF also increased metabolic flexibility (P = 0.0006) and decreased the 24-hour nonprotein respiratory quotient (Delta = -0.021 +/- 0.010; P = 0.05). Conclusions Meal-timing interventions facilitate weight loss primarily by decreasing appetite rather than by increasing energy expenditure. eTRF may also increase fat loss by increasing fat oxidation.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available